Complete selection of Organ/Tissue Baths and Full Perfusion Systems. Twenty eight systems to choose from to meet your research needs. Staff scientists available for system consultations.
BTX offers a comprehensive line of instruments and accessories for both electroporation and electrofusion of mammalian, bacterial, yeast, fungi, insect and plant cells and tissues. BTX specializes in providing research tools for novel cutting edge applications such as adherent cell electroporation, high-throughput cloning, in vivo gene delivery, in ovo gene delivery, and in & ex utero gene delivery.
Panlab features a set of operating board for general surgical work on small laboratory animals. These one-piece molded boards hold rodents and other small animals during surgery and provide excellent access to the entire length of the animal. Four slots are positioned in the corners of the platform for allowing large and small animals to be held firmly in place. The platform has grooves running both its length and width for drainage or placement of the flushing line during surgery. The tables are mounted on a traditional tripod stand allowing the platform to easily tilt in various directions. Non-slip feet insure a stable position of the system during the whole surgery process.
Two different models are available:
- The Panlab OT100 Rodent Surgery Table offers a convenient, non-absorbent and easy-to-clean PVC platform. The middle part of the platform is also provided with a set of longer slots for fixing some user-defined surgical accessories.
- The Panlab OT200 Rodent Surgery Table is a homoeothermic table allowing the control of animal temperature during surgery. The operating board is constructed of an extremely durable anodized aluminium platform allowing a uniform heat distribution. The heat of the platform is maintained by the HB 121 Control Unit, working with a DC power supply to minimize any AC ripple interference with the registration of some animal physiological measurements, such as electrocardiogram. The unit allows the user to adjust the body temperature between 34 to 45°C. The heat is maintained by the table-associated temperature probe or a rectal thermistor probe. Table heat and animal body temperatures can be visualized simultaneously on two different displays on the HB121 control unit.
Material Composition |
PVC (OT100) or anodized aluminium (OT200) |
OT100 Dimensions |
32 (W) x 22 (D) x 10 (H) cm |
OT200 Dimensions |
28 (W) x 21 (D) x 10 (H) cm |
OT500 Dimensions |
70 (W) x 40 (D) x 10 (H) cm |
Components included |
Board, tripod stand, Four slots for holding the animal in position, two slots for fixing surgery accessories (OT100 model) |
OT100 |
76-0287 |
Small animals operating tilting table. |
OT200 |
76-0288 |
Small animals operating homeothermic table. |
OT500 |
76-0289 |
Medium size animals operating table. |
HB121 |
76-0290 |
Temperature control for OT200. Includes rectal probe. |
For more details about surgery tables in experimentation, consult the following link
The goal of a drug discovery effort is to generate novel, highly selective molecules that either inhibit or activate processes in the cell to ultimately produce therapeutic effects in humans.
Panlab proposes two multi-channel digital thermometer models suitable for the measurement of animal body temperature using rectal probes. Both systems are designed for working with up to 12 resistive-temperature probes simultaneously.
Temperature is measured by using Yellow Springs (YSI) thermistor and the registered current value shown in the digital display of the front panel with a resolution of 0.1 degrees (sensitivity range: 32-45°C). There is no difference between channels or temperature probes, freely interchangeable. Standard YSI temperature probes should be plugged in the jack connectors of the rear panel, while the temperature value is read from the front panel display.
TMP812 model allows the reading of the current temperature of one channel at once. The selection is done by switching the desired channel in the 12-positions front panel rotary commuter.
TMP812RS model offers a 20x4 LCD display for showing the current temperature of all the probes at the same time. A built-in RS 232/USB communication port, allows sending (by pressing a front panel “SEND” button) the temperature values from all the probes to an external device (matrix printer with serial port or PC computer) through the SEDACOM software.
The new SEDACOM 2.0 version provides an easy and convenient way to visualize and export the data on a computer for further analysis.
Resolution |
0,1 degrees Celsius |
Capacity |
Up to12 temperature probes simultaneously |
Temperature probes |
Standard YSI probes |
Communications |
RS232 (USB) |
CONTROL UNIT |
||
TMP812RS |
76-0065 |
12 Channels Digital Thermometer with RS232 port comms. Probes and SeDaCom software should be ordered separately. |
TEMPERATURE PROBES |
||
YS401 |
76-0066 |
Temperature probe for rabbits (3.9 mm) |
YS402 |
76-0067 |
Temperature probe for rats & mice (3 mm) |
YS451 |
76-0068 |
Temperature probe for mice (1.3 mm) |
YS409 |
76-0069 |
Surface temperature probe (disc dia. 9.5 mm) |
DATA TRANSFER & SOFTWARE |
||
SEDACOM V2.0 |
76-0406 |
SeDaCom V2.0 software for data transfer to a computer |
CONRS232USBHS |
76-1132 |
SeDaCom accessory - RS232/USB adapter |
See more information about body temperature evaluation in rodents in next link
Panlab provides a complete set of precise, compact and easy-to-use single-, double- or four-channels digital stimulators for general pharmacology and physiology such as organ/tissue bath studies.
With a wide range of stimulation parameters, these stimulators offer an excellent and low priced alternative when single pulse and train stimulation is required.
BASIC STIMULATOR LE12006 |
|
Number of Channels |
1 channel |
Pulse Frequency |
0.01 - 99.99 Hz (0.01 Hz step) |
Pulse Duration |
0.1 - 9.9 ms (0.1 ms step) |
OUTPUT Voltage |
0 - 50 V (1 V resolution) |
OUTPUT Max. Power |
15 W (250 mA) |
Accuracy |
≤ 4% for timings and output |
Power Supply |
125/220V, 50/60Hz |
PULSE GENERATOR |
|
PULSE Frequency |
1 Hz - 10 KHz (1 Hz step) |
PULSE Duration |
1 - 9999 μs (1 μs step); 1 - 9999 ms (1 ms step) |
TRAIN Interval |
0.1 - 999.9 s (1 s step) |
TRAIN Duration |
1 - 99.99 s (0.01 s step) |
DIGITAL OUTPUT |
5 V (TTL) |
Accuracy |
≤ 2% for timings and output |
POWER UNIT |
|
OUTPUT Voltage |
0 - 100 V (1 V resolution); constant voltage (automated short circuit security) |
OUTPUT Current |
0 - 500 mA (5 mA resolution); constant current (automated short circuit security). Except for LE 12106: 0 - 100 mA (1 mA resolution); constant current (automated short circuit security) |
OUTPUT Max |
Power 50 W per channel (500 mA) |
COMPACT SYSTEMS |
Dimensions (W x D x H) |
||
LE12006 |
76-0061 |
1-Channel Basic Stimulator for teaching purpose |
29 x 27 x 7 cm |
LE12106 |
76-0055 |
1-Channel Digital Stimulator including 1 Pulse generator and 1 Power unit |
34 x 31 x 15 cm |
LE12206 |
76-0057 |
2-Channels Stimulator including 2 Pulse generators and 2 Power units |
45 x 35 x 19 cm |
LE12406 |
76-0587 |
4-Channels Stimulator including 1 Pulse generator and 4 Power units |
45 x 35 x 19 cm |
MODULAR SYSTEMS |
|
||
LE12406OM |
76-0058 |
Power Unit module (LE12406TC needed) |
7 x 12 x 17 cm |
LE12406TC |
76-0059 |
Pulse Generator & Mainframe module for up to 4 LE12406OM units |
45 x 35 x 19 cm |
LE12404 |
76-0060 |
Mainframe module for up to 4 LE12406OM units (External Pulse generator needed) |
45 x 35 x 19 cm |
LE12806 |
|
8-Channels Stimulator package including 1 LE12406TC, 1 LE12404 and 8 LE12406OM |
2 x (45 x 35 x 19 cm) |
OTHER ACCESSORIES |
||
TRS081 |
76-0062 |
Nerve Electrode |
TRS082 |
76-0063 |
Bipolar Electrode |
The PANLAB Coupler Module ISO510A is an Amplifier for bridge-system designed to work with a wide range of different transducers for evaluating pressure, strength or respiration in various research areas. As an example, the ISO510 model is currently associated with the isometric or isotonic transducers for the study of in vitro tissues preparations using Organ Baths.
The PANLAB ISO510A Amplifier can work in both AC and DC and amplifies signal up to 2.000 times. The Amplifier contains a filter allowing the suppression of the noise produced by electrical or mechanical artefacts associated with the experiment running (for instance, ventilation and heating pump systems in Organ Baths) and then eliminates vibrations that may affect the signal received from the biological preparations. A Transducer Balance option allows a fine adjustment of the signal baseline (“zero”) when the transducer is not excited by the variable to be measured. The ISO510A amplifier also allows the external monitoring of its output signal, for instance to an oscilloscope…
The ISO510A Amplifier is available in two versions: individual Amplifiers accompanied with the corresponding external Power Supply Box or individual Amplifiers integrated into the Power Supply Box.
Gain |
0-2000 |
Input Impedance |
1.5 kOhms |
Output Impedance |
< 100 Ohms |
Feed Power |
18 VDC |
Output Voltage |
10 V |
Transducer Power Supply |
10 VDC |
Band Frequency |
0-5 KHz |
Filters |
>3 Hz or >20 Hz |
Filter AC |
0.16 Hz |
Connector |
5 pin Female Audio Connector |
Certification |
CEE Compliance |
ISO510A |
76-0627 |
Needs a Power Supply Box |
BR4740A |
76-0586 |
Power Supply Box for up to 4 Amplifiers ISO510A |
For more details about the isolated organ/tissue method, consult the following link
For more details about standard integrated organ bath solutions, consult the “Related Integrated solutions” section of the Isolated organ/tissue test – organ bath webpage – link
Panlab provides complete hardware solutions and associated software for isolated tissues studies from simple, manual systems to automated, computer-controlled systems.
The mechanical activity of the tissues (muscles) is formed by a displacement (elongation) and a force (contraction). The ratio between elongation and force depends on the properties of the tissue under study: some tissues exhibit a mechanical response with a very large displacement and a reduced force; other tissues produce short but very intense contractions (in terms of strength). Depending on this ratio, the transducer used for performing an organ bath experiment will be isometric or isotonic.
- Isometric transducers
The Panlab Force/Isometric Transducers measures the force of contraction of isolated tissues under conditions of constant force.
Isometric force transducers are very sensitive to the force applied under conditions contraction with very short amplitude (low displacement). As an example, the Transducers of weight of the electronic scales acts in an isometric way. Generally the isometric technology is also used to measure frequencies; for this reason, the displacement of the sensor of the transducer need to be as slight as possible. Panlab has transducers with a minimum displacement of 0.1 mm for a force application until 25 grams.
Isometric Transducers are classically used in Organ Bath experiments with muscles with short/rapid contractions such as tracheal muscle, atrium, papillary muscle, aortic rings, veins or other vessel rings.
The Transducers are equipped with a special system allowing an easy and rapid fixation of the thread that tightens upper side of the tissue in an organ bath. Panlab provides transducer for various load range, from teaching to standard research systems.
- Isotonic transducers
The Panlab Isotonic Transducer measures displacements with pre-adjusted loads (position transducer).
Isotonic transducers are classically used for measuring the contraction amplitude of isolated muscles in Organ Bath studies, i.e. the changes in tissue length observed under a constant load.
To achieve this capacity, an isotonic transducer must possess a sensor axis which rotates at least 25 degrees. This type of register was the one which was used initially, at the time of the kymographs in such a way that the transducer was configured by a lever, balancing on a pivot.
These transducers are preferably used with smooth muscle preparations characterized by relatively slow contractions (ileum, vas deferens, lung strips, esophagus, urinary bladder, etc.).
Download here the Transducer leaflet – link
Although in principle and from the physiological point of view, the most appropriate for smooth musculature is the isotonic and for heart and striate the isometric, in purity all animal muscle contracts partly isotonically and partly isometrically. Nowadays all the tasks are done with isometric as the response is much more repetitive, the basal line is much more constant, and the relaxation much more rapid. Isotonic transducers are only used in few specific cases
Recommended bibliography:
Kitchen I. Textbook of in vitro practical pharmacology. Blackwell Scientific Publications. Oxford, 1984
Type |
Isometric (Force) |
Isotonic |
||
Model |
TRI201 |
TRI210 |
TRO015 |
|
Feature |
High sensitivity |
Teaching |
Displacement |
|
Range |
5 mg to 25 g |
10 mg to 25 g |
5 mg to 5 g |
|
Resolution |
2 mg |
5 mg |
5 mg |
|
Displacement |
± 0.45 mm |
± 0.5 mm |
± 15 º (48 mm) |
|
Sensitivity |
32 μV/V/g |
25 μV/V/g |
24 μV/V/º |
|
Power Supply |
5-10 V dc/ac |
5-10 V ac/dc |
5-10 V dc |
|
ROD Length (6mm dia.) |
165 mm |
165 mm |
150 mm |
|
Counterweight graduation |
|
|
5 div of 1 g with subdiv of 250 mg |
|
5 pin female audio connector |
6 pin male binder connector |
8 pin male connector |
|
Transducer connector for Panlab ISO510A amplifier and ADinstrument Bridge pod. |
Transducer connector for Hugo Sachs amplifiers. |
Transducer connector for ADinstruments amplifiers. |
|
TRI201A (76-0575) |
TRI201HS (76-0418) |
TRI201AD (76-0417) |
|
TRI210A (76-0098) |
TRI210HS (76-0579) |
TRI210AD (76-0581) |
|
TRO015A (76-0583) |
TRO015HS (76-0424) |
TRO015AD (76-0423) |
Five pin male connectors for Panlab previous ISO510 amplifier are obsolete but can be provided under specific request.
For more details about the isolated organ/tissue method, consult the following link
For more details about standard integrated organ bath solutions, consult the “Related Integrated solutions” section of the Isolated organ/tissue test – organ bath webpage – link
Panlab provides complete hardware solutions and associated software for isolated tissues studies from simple, manual systems to automated, computer-controlled systems.
PROTOWIN is a complete software for monitoring isolated tissue experiments. It represents a very powerful tool saving the user time and effort in the awkward calculations involved in this research area. Its interactive design makes it very easy to use and its extensive features make it an essential tool for teaching and research.
Basically, PROTOWIN software allows the acquisition and analysis of signals generated by the contraction of isolated organ preparations maintained into an Organ Bath and challenged by drugs exposure or electrical stimulation.
The software can analyze and store signals form up to 4 channels (i.e. from up to 4 tissue preparations) simultaneously or in an independent manner. The analogical signal charts can be viewed on the screen one by one or in sets of four units at a time. Independent adjustment of full scale range, time axis and offset are available for each channel, as well as independent base–maximum plot for each point.
The system facilitates the extraction of data into a spreadsheet for further analysis. Regular data Back-up is automatically performed as a safety measure in case of accidental computer shutdown.
PROTOWIN V1.1 |
76-0038 |
Software for Organ Bath. Up to 4 channels. Dose/Response. |
For more details about the isolated organ/tissue method, consult the following link
For more details about standard integrated organ bath solutions, consult the “Related Integrated solutions” section of the Isolated organ/tissue test – organ bath webpage – link
Panlab provides complete hardware solutions and associated software for isolated tissues studies from simple, manual systems to automated, computer-controlled systems.
The Panlab Compact Organ Baths have been designed and developed to satisfy the requirements of investigators by offering advanced characteristics that render them suitable for the in-vitro study of tissue behavior. Due to their compact design minimum bench space is required.
The modular design allows up to eight individually mounted tissues to be studied simultaneously and independently per system. Several models are available, from one up to eight chambers. All of them are supplied with an external heating control unit, transducer' stands & micropositioners and tissue holders. The main Perspex reservoir houses the heater system, the chambers and coils, all submerged in thermostatically controlled water. Each vessel is filled and emptied by means of a three-way tap (Manual Series) or by electrically-operated valves (Automatic Series) which, besides the possibility of manual activation by means of frontal pushbuttons, can also be remotely controlled by a Timer or Programmer (Software).
All organ baths include tissue holders, transducer holders, micropositioners. The tissue chambers are sold separately.
Panlab can too supply suitable Isometric or Isotonic Force Transducers.
Standard solution for teaching uses the LE120-1 or LE120-2 flat recorders for recording the signals on paper. Optionally, the PANLAB Modular Organ Baths can be associated with transducers, amplifiers and data output software from several brands.
Cost-saving and straight-to-the-point solution is available as a combination with the Panlab transducers, amplifiers and PROTOWIN software.
The Panlab organ baths are also the main piece of the ADInstruments organ baths working with the Powerlab and LABChart software systems and proving advanced data report options.
Download here the Panlab Organ bath leaflet – link
COMPACT ORGAN BATHS (Chambers not Included) |
|||||||
Chambers |
Dimensions (cm) |
Tank (liters) |
Manual |
Automatic |
|||
2 |
Base: 28 x 20; Height: 27 + 22 |
5 L |
LE01002 |
76-0030 |
LE01026 |
76-0031 |
|
4 |
Base: 44 x 20; Height: 27 + 22 |
8 L |
LE01004 |
76-0032 |
LE01046 |
76-0033 |
|
6 |
Base: 60 x 20; Height: 27 + 22 |
11 L |
LE01006 |
76-0034 |
LE01066 |
76-0035 |
|
8 |
Base: 76 x 20; Height: 27 + 22 |
14 L |
LE01008 |
76-0036 |
LE01086 |
76-0037 |
CHAMBERS |
||
LE0105 |
76-0044 |
5 mL |
LE0110 |
76-0045 |
10 mL |
LE0125 |
76-0046 |
25 mL |
LE0150 |
76-0047 |
50 mL |
ELECTRODES & STIMULATORES |
||
LE01030A |
76-0048 |
Stainless steel electrode |
LE01030B |
76-0049 |
Stainless steel electrode. Two rings, 20 mm. apart |
LE01030C |
76-0050 |
Stainless steel electrode. Two rings, 15 mm apart |
LE01030D |
76-0051 |
Stainless steel electrode. Surface contact |
LE01035A |
76-0052 |
Platinum electrode. Single ring |
LE01035B |
76-0053 |
Platinum electrode. Two rings, 20 mm apart |
LE01035C |
76-0054 |
Platinum electrode. Two rings, 15 mm apart |
LE01035D |
76-0393 |
Platinum electrode. Surface contact |
STIMULATORS |
|
See available Panlab options in next link |
TRANSDUCERS (see Related product) |
AMPLIFIERS (see Related products) |
DATA OUTPOUT |
||
PROTOWIN V1.1 |
76-0038 |
Software for Organ Bath. Up to 4 channels. Dose/Response. |
For more details about the isolated organ/tissue method, consult the following link
For more details about standard integrated organ bath solutions, consult the “Related Integrated solutions” section of the Isolated organ/tissue test – organ bath webpage – link