The forced swimming test is a relatively simplistic and widely used model for testing depression. The forced-swimming paradigm was originally adopted by Porsolt et al. (1978). Naïve rats and mice forced to swim in a transparent cylinder (aversive and confined environment) innately fight to escape the apparatus. Following failed attempts to escape, they become immobile (i.e. float), a behavior generally considered as despair or “depressive-like”. Prior treatment with antidepressants decreases the time spent immobile and increases the latency to reach the first immobility episode.
We provide several different sized transparent cylinders for the forced swimming test. All cylinders are made of Perspex Acrylic.