The use of rectal probes associated to digital thermometers is one of the most classical procedures used in this context as it represents an easy and accurate way to measure animal body core temperature.
Animal body temperature is a key factor to control in a wide variety of pharmacological and behavioral experiments: surgery, evaluation of pain sensitivity to thermal stimuli, evaluation of blood pressure using the non-invasive method, etc…
Surgery tables are classically used for completing general surgical work on small laboratory animals.
Anesthesia induction is the first step of the anesthesia process when general anesthesia is required in the experiment procedure (pain models, electrophysiology, lesions, stereotaxy etc…).
The forced swimming test is a relatively simplistic and widely used model for testing depression. The forced-swimming paradigm was originally adopted by Porsolt et al. (1978). Naïve rats and mice forced to swim in a transparent cylinder (aversive and confined environment) innately fight to escape the apparatus. Following failed attempts to escape, they become immobile (i.e. float), a behavior generally considered as despair or “depressive-like”. Prior treatment with antidepressants decreases the time spent immobile and increases the latency to reach the first immobility episode.
We provide several different sized transparent cylinders for the forced swimming test. All cylinders are made of Perspex Acrylic.
Tru Scan is a versatile and simple system to monitor open field activity.
Utilizing interchangeable sensor rings, Tru Scan ensures precise tracking in up to three planes. Nose poke task, place preference, conditioned freezing, light/dark tests can also be performed in our Tru Scan test arenas.
Additional accessories, such as shock floors, video mounted TV cameras, high-brite cue, noise/tone generators and wall mounting brackets are available for use with the system, making Tru Scan extremely functional and flexible.
Experimental protocols are setup through a simple point-and- click user interface, saved and recalled by number for future use. All selected data is compiled and analyzed according to the parameters defined in the protocol.
Versatility and simplicity are the defining benefits of Tru Scan. All selected data is gathered, analyzed and presented in the same way whenever the experimental protocol is run without reselection.
The software also features subject, operator and protocol IDs as well as automatic data storage and stimulus presentation, if desired. Data analysis is fully automated for each subject or across subjects with results presented in a table or graphically. Results are calculated for all userselected parameters. Graphical data can be copy-pasted directly into publication documents.
Data is stored as raw coordinate sets with real time date stamps for each of the sensor rings used. This allows experiments to be re-run without animals to re-analyze data, using more and shorter histogram bins or new data elements to find other behaviors or effects not observed in the original analysis. This unique feature minimizes the number of animals needing to be tested. Raw data may also be easily exported to a spreadsheet for further statistical analysis.
The Tru Scan system offers two arena sizes – one for mice and one for rats – thus optimizing environmental area and beam spacing to be appropriate for each species, resulting in greater overall system accuracy. A slide-out floor/drop pan facilitates easier maintenance. Tru Scan stimulus accessories are available for increased flexibility of the system. Nose poke task, place preference, conditioned freezing, light/dark test can also be performed with the Tru Scan test arenas.
See the Coulbourn web page for more information about this product