Vogel test

Description

The Vogel test paradigm is a popular conflict model in which water-deprived rats and mice first learn to lick from a water spout in an operant chamber.

Then, usually after a period of unpunished licking, responses are punished with mild footshocks, inducing a significant reduction of drinking. In this context, administration of anxiolytics is shown to inhibit shock-induced drinking suppression.

VOGEL TEST - MICE – PACKWIN (Panlab)

1 x 76-0316/LE862 Vogel box for mice
1 x 76-0334/LE10025 control unit for shock & lick detector (1 for each box)
1 x 76-0156/LINKBOX01 Linkbox unit (1 for each 8 x LE10025)
1 x 76-0002/PACKWIN V2.0 - Software platform to control up to 8 LINKBOX01, so up to 32 Vogel boxes!)
1 x 76-0594/PACKWINVT Specific experimental module for Vogel test experiments
1 x 76-0592/PACKWINCS Customizable experimental module - full flexibility for operant procedures (Optional)

VOGEL TEST - RAT – PACKWIN (Panlab)

1 x 76-0321/LE865 Vogel box for mice
1 x 76-0334/LE10025 control unit for shock & lick detector (1 for each box)
1 x 76-0156/LINKBOX01 Linkbox unit (1 for each 8 x LE10025)
1 x 76-0002/PACKWIN V2.0 - Software platform to control up to 8 LINKBOX01, so up to 32 Vogel boxes!)
1 x 76-0594/PACKWINVT Specific experimental module for Vogel test experiments
1 x 76-0592/PACKWINCS Customizable experimental module - full flexibility for operant procedures (Optional)

Reasons for choosing this test

Punishment based conflict test

Reasons for not choosing this test

Classically used in rat, underemployed in mice
Needs food or drink deprivation
Involves aversive/stressful stimulus (footshock)
Influenced by non-specific changes in response rate, cognition, basal water/food intake and nociception

Related human disease/applications

Anxiety
Drug screening

Panlab | Harvard Apparatus