In basic research Microdialysis is an indispensable tool for drug discovery. CMA’s solutions are used across the globe by drug developers and researchers to achieve fast and efficient drug discovery. CMA´s vision is: To substantially shorten the time-to-market of drug and research projects by offering a complete and leading portfolio of Microdialysis products.
Microdialysis is a unique technique to monitor the chemistry of the extracellular space in living tissue. In basic research it is primarily used for In Vivo determinations of endogenous compound changes, drug delivery, PK/PD, bioavailability and bioequivalence.
The Microdialysis probes designed to mimic a blood capillary have a semi-permeable membrane that, when perfused with a physiological salt solution, allows an exchange of compounds from an area of high concentration to an area of low concentration. A representative proportion of molecules from the extracellular fluid is then carried to the probe outlet for collection and analysis.
Follow the Product Links for more information about the CMA Microdialysis instruments used for the fluids infusion and collection:
- CMA 120 Enclosures for freely moving animals
- CMA 110 Liquid switch
- CMA 111 Syringe selector
- CMA 130 In vitro stand
- CMA 450 Temperature controller
- CMA 142 microfraction collector
- CMA 470 refrigerated fraction collector