PAW & TAIL PRESSURE – Randall Selitto

for evaluating mechanical pain sensitivity in rat

Description
Key features
Specs
How to order
Publications

Description

The Panlab LE7306 paw & test pressure meter is used for performing the Randall & Selitto test in rodents.

Description

This test is based on determination of the animal threshold response to pain induced by the application of a uniformly increasing pressure on the paws or the tail.

This test can be used on both rats and mice. On rat, it is commonly used for paw pressure. On mice, it is commonly for tail pressure. It is possible to use this test on mice paw but it’s moer challenging so the experimenter needs to be particularly skilled.

In the LE7306 paw & paw pressure model, a stimulation unit allows the gradual and constant increase (at selectable rates) of the pressure applied on the animal paw or tail. The pressure increase is achieved by a step-motor inducing the progressive advancement of a sliding support with a distal tip.

The motor and tip are mounted on a pivoting stand preventing any excess pressure on the animal paw. The Control Unit makes possible the adjustment of the force transducer, balance and reset, as well as the selection of the step-motor current speed.

Included accessories

The pressure meter is provided with 2 tips (1 pointed tip and 1 flat tip). The different tips are used for changing the dimension of the area of the mechanical stimulation. Both tips can be used in rats or mice or on the paw or the tail.

A remote foot-switch controls the motor turn on/off allowing rapid hands-free experiments. An automatic mechanism is activated once the distal extreme of the sliding support track is reached or when the pedal is released at the test ending point. Then, the motor reverse its rotation at its higher speed, sliding up the conic tip again.

Software

The optional SeDacom software 2.0 can be used and represents an easy and convenient way to visualize and export the data on a computer for further analysis.

Examples

See this clear example of the use of the Panlab Paw & Tail pressure meter applied on the mouse tail: link

Specs

Power Supply 110V/220V, 50/60Hz
Stimuli Resolution 1 gram
Maximum Stimuli 999 gram
Material Composition Methacrylate
Maximum number of stations 1 per computer (multiple set-ups also available under request)
Certifications CE Compliant
Control Unit Dimensions 350 (W) x 350 (D) x 130 (H) mm
Stimulation Unit Dimensions 150 (W) x 210 (D) x 166 (H) mm

Publications

  • Balakumar M et al. (2013) Benefits of early glycemic control by insulin on sensory neuropathy and cataract in diabetic rats. Indian J Exp Biol. 2013 Jan;51(1):56-64. (Paw pressure, rat, India)
  • Spanevello MD et al. (2013) Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats. J Neurotrauma. 2013 Jun 15;30(12):1023-34. (Paw pressure, rat, Australia)
  • Weibel R et al. (2013) Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice. PLoS One. 2013 Sep 12;8(9):e74706. (Tail pressure, mouse, France)
  • Sánchez Robles EM et al. (2012) Cannabinoids and muscular pain. Effectiveness of the local administration in rat. Eur J Pain. 2012 Sep;16(8):1116-27. (paw pressure, rat, Spain)
  • Elhabazi K et al. (2012) Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. Br J Pharmacol. 2012 Jan;165(2):424-35. (Tail pressure, mouse, France)
  • Fernández-Dueñas V et al (2008) Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: Prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat Eur. J. Pain, 12(Issue 2):157-163 (rat, Spain)
  • Célérier E et al. (2006) Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase. Anesthesiology 104(3): 546-555. (Paw-pressure, mouse, Spain)
  • Puig MM et al. (2006) Opioid-induced hyperalgesia in a murine model of postoperative pain. Anesthesiology. 2006 Mar;104(3):546-55. (Paw-pressure, Mice, Spain)
  • Romero A et al (2005) Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw. Eur. J. Pharmacol. 511(2-3):207-217. (rat, Spain)
  • Célérier E et al. (2004) Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase C-gamma gene. Neuropharmacol. 46:264-272. (Tail-pressure, mouse, Spain)
  • Al-Naggar TB et al. (2003) Neuropharmacological activity of Nigella sativa L. extracts. J. Ethnopharmacol. 88(1): 63-68. (rat, Spain)
  • Gutierrez M et al. (2003) Interactions of acute morphine with chronic imipramine and fluvoxamine treatment on the antinociceptive effect in arthritic rats. 352(Issue 1): 37-40. (rat, Spain)
  • Martin M et al. (2003) Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones Eur. J. .Neurosci. 17(4):701 (Tail-pressure, mouse, Spain)
  • Martin M et al. (2003) Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice. Mol. Brain Res. 110(1):109-118. (Tail pressure, mouse, Spain)
  • Kim HW et al. (2002) The antinociceptive properties of Ethylacetate extracts from Bang-Poong (Radix Ledebouriellae) on the Freud’s Adjuvant-Induced Arthristis in Rats. J. Vet. Sci. 3(4): 343-9. (rat, South Korea).
  • Kwon YB et al. (2002) The water-soluble fraction of bee venom produces antonociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sciences 71: 191-204 (rat, South Korea)
  • Kwon YB et al. JH (2001) Bee venom injection into an acupuncture point reduces arthritis associated oedema and nociceptive responses. Pain 90 (2001) 90(3):271-80 (rat, South Korea)
  • Lee JH et al. (2001) Bee venom pretreatment has both an antinociceptive and anti-inflammatory effect on carrageenan-induced inflammation. J Vet Med Sci. 63(3):251-9. (rat, South Korea)
  • Planas E et al. (2000) Antinociceptive/Anti-Edema Effects of Liposomal Morphine during Acute Inflammation of the Rat Paw Pharmacology 60:121-127 (Paw-pressure, rat, Spain)

 

How to order

CONTROL UNIT & STIMULUS

LE7306

76-0234

Paw Pressure system, RS232 port., including 2 cones. SEDACOM software and RS232/USB converter have to be purchased separately.

 

DATA TRANSFER & SOFTWARE  

SEDACOM V2.0

76-0406

SeDaCom V2.0 software for data transfer to a computer.

CONRS232USB

76-0608

SeDaCom accessory - RS232/USB adapter.

LE7000

76-0114

Thermal Printer.

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Digital display
  • Pressure increasing rate adjustment
  • Foot-switch control
  • New optional Data Transfer software SEDACOM 2.0 

 

Related tests

Randal & Selitto test

 
 
 
 
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