ROTAMETER

for evaluating rotation behaviour in rodents

Description
Key features
Specs
How to order
Publications

Description

Rotational behaviour has proved a popular technique for screening the behavioural effects of a wide variety of lesions, drugs, and other experimental manipulations on the brain of rodents. This test is widely carried out in experiments using animal models of Parkinson disease with unilateral lesions in the dopaminergic nigrostriatal system.

Basically, the subject wears an adjustable harness with a soft ring connected to the rotation sensor by a flexible tie. The subject is then placed into a transparent container (cylinder or bowl) with a lateral support for a vertical stand. 

A bi-directional rotation sensor provides a double (right and left turns) output with adjustable regulation of pulses/turns. Two configurations are available for rotation counting: individual counter or a multicounter.

When using a multicounter, the new SEDACOM 2.0 version provides an easy and convenient way to visualize and export the data on a computer for further analysis.

 

Specs

Fraction of turn units of ¼ turns (selectable)
Dimensions of the containers Cylinder 400 mm diameter - 300 mm height; Bowl 400 mm diameter - 200 mm height

Publications

  • Frau L et al. (2013) Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons. Exp Neurol. 2013 Sep;247:663-72. (rat, Italy)
  • Gago B et al. (2013) l-dopa-induced dyskinesias in unilateral 6-hydroxydopamine-lesioned rats are not modified by excitotoxic lesion of the entopeduncular nucleus and substantia nigra pars reticulata. Synapse. 2013 Jul;67(7):407-14. (rat, Spain)
  • Lorenc-Koci E et al. (2013) Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA. Neurochem Int. 2013 Sep 30;63(8):790-804. (rat, Poland)
  • Sogabe S et al. (2013) Mesocortical dopamine system modulates mechanical nociceptive responses recorded in the rat prefrontal cortex. BMC Neurosci. 2013 Jul 2;14:65. (rat, Japan)
  • Ramos-Moreno T et al. (2012) Clonal Human Fetal Ventral Mesencephalic Dopaminergic Neuron Precursors for Cell Therapy Research. PLoS One. 2012;7(12):e52714. (rat, Spain)
  • Ramos-Moreno T et al. (2012) Long term behavioral effects of functional dopaminergic neurons generated from human neural stem cells in the rat 6-OH-DA Parkinson's disease model. Effects of the forced expression of BCL-X(L). Behav Brain Res. 2012 Jun 15;232(1):225-32. (rat, Spain)
  • Garbayo E et al. (2011) Long‐term neuroprotection and neurorestoration by glial cell‐derived neurotrophic factor microspheres for the treatment of Parkinson's disease. Mov Disord. 2011 Aug 15;26(10):1943-7. (Parkinson, rat, Spain)
  • Onozawa K et al. (2011) Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex. BMC Neurosci. 2011 Nov 15;12:115. (rat, Japan)
  • Serra Sánchez DT et al. (2011) Establishment of the conditions for the bone marrow cells transplants in a model of Huntington´ s disease and functional effect on the motor behavior. Rev. colomb. biotecnol vol.13 no.2 Bogotá July/Dec. 2011 (Huntington rat, Colombia)
  • Courtois ET et al. (2010) In Vitro and in Vivo Enhanced Generation of Human A9 Dopamine Neurons from Neural Stem Cells by Bcl-XL. J. Biol. Chem. 285: 9881-9897 (rat, Spain).
  • Pinna A et al. (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology. 58(3):613-623. (rat, Italy)
  • Kasture S et al. (2009) Assessment of Symptomatic and Neuroprotective Efficacy of Mucuna PruriensSeed Extract in Rodent Model of Parkinson’s Disease. Neurotoxicity Res. 15(2):111-122. (rat, India, Italy)
  • Garbayo E et al. (2009) Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease. J. Controlled Release. 135(2): 119-126. (rat, Spain, France)
  • Simola N et al. (2009) Priming of rotational behavior by a dopamine receptor agonist in hemiparkinsonian rats: Movement-dependent induction. Neuropharmacology. 158(4):1625-1631. (rat, Italy)
  • Belzunegui S et al. (2008) Striatal carotid body graft promotes differentiation of neural progenitor cells into neurons in the olfactory bulb of adult hemiparkisonian rats. Brain Res. 1217:213-220 (rat, Spain)
  • Diaz-Véliz G et al. (2008) Copper Neurotoxicity in Rat Substantia Nigra and Striatum Is Dependent on DT-Diaphorase Inhibition. Chem. Res. Toxicol. (rat, Chile, France)
  • Simola N et al. (2008) Blockade of globus pallidus adenosine A2A receptors displays antiparkinsonian activity in 6-hydroxydopamine-lesioned rats treated with D1 or D2 dopamine receptor agonists. Synapse. 62(5): 345-351. (rat, Italy)
  • Martín AB et al. (2007) Expression and Function of CB1 Receptor in the Rat Striatum: Localization and Effects on D1 and D2Dopamine Receptor-Mediated Motor Behaviors. Neuropsychopharmacology. 33: 1667-1679. (rat, Spain)
  • Aymerich MS et al. (2006) Consequences of unilateral nigrostriatal denervation on the thalamostriatal pathway in rats. Eur. J. Neurosci. 23(8): 2099. (rat, Spain)
  • Bove J et al. (2006) Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats. Synapse. 59(7): 435-444. (rat, Spain)
  • Pérez-Manso M et al. (2006) 'Functional'neuroanatomical tract tracing: Analysis of changes in gene expression of brain circuits of interest. Brain Res. 2006 Feb 9;1072(1):91-8. (Parkinson, rat, Spain)
  • Romero CA et al. (2006) Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats. Neurotoxicity Res. 10(1): 11-22. (rat, Chile, Sweden)
  • Diaz-Veliz G et al. (2004) Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats. Neurotox Res. 2004;5(8):629-33. (rat, Chile)
  • Toledo-Aral JJ et al. (2003) Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats. J. Neurosci. 23(1): 141-148. (rat, Spain)
  • Segura-Aguilar J et al. (2002) Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like Rotational Behaviour. Neurotoxicity Research, Volume 4, Number 2, 127 – 131 (rat, Chile)
  • Diaz-Veliz G et al. (2002) Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra. Pharmacol Biochem Behav. 73(4):843-50 (rat, Chile)
  • Casas M et al. (1999) Rotational behavior in dopamine nigrostriatal denervated rats: effects of a wide range of time intervals between apomorphine administrations. Pharmacol Biochem Behav. 1999 Mar;62(3):481-5. (rat, Spain)

 

How to order

ROTATION SENSORS

LE902SR

76-0244

Left & Right Rotation Sensor, adjustable turn resolution.

 

HARNESS

LE902AS

76-0245

Rat Harness (soft ring design) and connecting wire.

LE902ASE

76-0555

Mouse Harness (soft ring design) and connecting wire.

 

CONTAINER & SENSOR SUPPORT

LE902BT

76-0556

Bowl container with support (40 cm diameter, 20 cm height).

LE902RP

76-0247

Cylinder container with support (40 cm diameter, 30 cm height).

 

INDIVIDUAL COUNTER

LE902CC

76-0242

Individual Double Counter (left & right turns).

 

MULTICOUNTER 

LE3806

76-0243

 

Programmable MultiCounter with 30 inputs (up to 15 Rotameter) . SeDaCom Software has to be ordered separately

SEDACOM V2.0

76-0406

SeDaCom V2.0 software for data transfer to a computer

CONRS232USB

76-0608

SeDaCom accessory - RS232/USB adapter

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Cylinder or Bowl transparent containers
  • Rotation sensor with adjustable TTL output signal
  • Configuring experiment duration and time intervals of counting
  • Counting the number of partial and complete left and right turns
  • Easily adjustable harness (new design)
  • New optional Data Transfer software SEDACOM 2.0 (for Multicounter LE3806)

 

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