SHUTAVOID Software

For active and passive avoidance

Description
Key features
Specs
How to order
Publications

Description

SHUTAVOID software is an implemented version of the Panlab SHUTTLE-8 software offering a user-friendly interface to conduct active and passive avoidance procedures in an automated manner. 

The Software SHUTAVOID controls independently up to 8 Shuttle Boxes or Passive Cages. The software detects how many cages are physically present and activates the corresponding windows. The system includes a test mode to enables immediate and reliable checking of the functioning of all the elements of the experimental chamber. 

The program controls the presentation of visual and acoustic stimuli and shock duration, at the same time that it records the position of the experimental animal in each compartment of the experimental cage, deciding about stimuli presentation accordingly. 

Unlimited number of schedules can be defined and used either by common or different experimental cages. The protocol editor allows the configuration of all the basic parameters necessary to set an active and passive avoidance experiment: habituation period, duration of the inter-trial interval (fixed or randomized), activation and duration of the conditioned stimulus (light, sound or both), activation, latency and duration of the unconditioned stimulus (electrical shock), latency for considering the response as “null”, door status (open/closed), number of trials, cut-off time for response etc… 

The chambers can be defined as Independent (for classical active avoidance procedures), Master or Slaves (for yoked procedures in which the paired-yoked animals receive the same number and temporal pattern of stimuli as their master mates, but only the master animal controls the outcome of the response). 

The program runs automatically when the animal is detected in the cage (independently for each cage). During the acquisition of data, information about the protocol state, animal position and current data can be visualized for each cage on the corresponding control window. 

Data related to each of the observed animal responses are stored into result files that pick up the information acquired during the working session. The data files can be open and re-analyzed to generate ASCII-coded reports in which the information is summarized for each trial or groups of trials (user-defined). 

 

 

Specs

Computer requirements 2,2 GHz processor or higher (Celeron processor not supported), 2 Gb of RAM
Graphic Card Requirements 256 colours palette graphics card for 1024x768 pixels, 32-bit true colour RGB display.
Communication ports 1 free USB for the protection key; 1 free RS232 serial port for boxes connection (a USB-Serial adapter included in the software pack can be used when a RS-232 serial port is not available)
System requirements Windows™ XP (SP2 or higher), Vista 32, Windows 7 or Windows 8 compatible operating system.

Publications

  • Aso E et al. (2013) CB 2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice. J Alzheimers Dis. 2013;35(4):847-58. (active avoidance, mouse, 2013)
  • Díaz-Morán S et al. (2013) Gene expression in amygdala as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats. Behavioural Brain Research, Volume 252, 1 September 2013, Pages 422–431. (active avoidance, rat, Spain)
  • Estanislau C et al. (2013) Context-dependent differences in grooming behavior among the NIH heterogeneous stock and the Roman high-and low-avoidance rats. Neuroscience Research, in press (active avoidance, rat, Spain, Brazil)
  • Klusa V et al. (2013) Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats. Pharmacology Biochemistry and Behavior, Volume 106, May 2013, Pages 68–76 (rat, Latvia)
  • Lucas M et a. (2013) Hypothalamic Corticotropin-Releasing Factor is Centrally Involved in Learning Under Moderate Stress. Neuropsychopharmacology, in press (active avoidance, rat, Israel)
  • McIntosh A et al. (2013) The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats. Psychopharmacology (Berl). 2013 Jul;228(1):31-42. (conditioned emotional response, rat, UK)
  • Palència M et al. (2013) Helplessness-like escape deficits of NIH-HS rats predict passive behavior in the forced swimming test: Relevance for the concurrent validity of rat models of depression. World Journal of Neuroscience, 2013, 3, 83-92 (active avoidance, rat, Spain)
  • Pérez MA et al. (2013) Long-term omega-3 fatty acid supplementation induces anti-stress effects and improves learning in rats. Behav Brain Funct. 2013 Jun 14;9(1):25. (active avoidance, rat, Chile)
  • Aso E et al. (2012) Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease. Brain Pathology, Volume 22, Issue 5, pages 636–653. (active avoidance, mouse, Spain)
  • Aso E et al. (2012) CB1 agonist ACEA protects neurons and reduces the cognitive impairment of AβPP/PS1 mice. Journal of Alzheimer's Disease. Volume 30, Number 2 / 2012, Pages 439-459. (active avoidance, mouse, Spain)
  • Díaz-Morán S et al. (2012) Coping style and stress hormone responses in genetically heterogeneous rats: comparison with the Roman rat strains. Behavioural Brain Research, Volume 228, Issue 1, 1 March 2012, Pages 203–210. (active avoidance, rat, Spain, UK)
  • Lalanza JF et al. (2012) Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology, Volume 37, Issue 11, November 2012, Pages 1745–1754. (active avoidance, rat, Spain)
  • Nowak A et al. (2012) Social modulation in extinction of aversive memories. Behavioural Brain Research Volume 238, Pages 200–205. (mouse, Poland)
  • Woods et al. (2012) 5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms. British Journal of Pharmacology, Volume 167, Issue 2, pages 436–449. (rat, UK)
  •  Cernak I et al. (2011) The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice. Neurobiology of Disease, Volume 41, Issue 2, February 2011, Pages 538–551 (active avoidance, mouse, USA)
  • Gyertyán I et al. (2011) Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents. Neurochemistry International, Volume 59, Issue 6, November 2011, Pages 925–935. (active avoidance, rat, Hungary)
  • Jurado-Berbel P et al. (2011) Post-Training Isoflurane Anesthesia Affects Memory for Object Recognition but Not for Two-Way Active Avoidance Task. The Open Behavioral Science Journal, 2011, 5, 16-23. (active avoidance, rat, Spain)
  • Lopez-Aumatell R et al. (2011) Effects of environmental and physiological covariates on sex differences in unconditioned and conditioned anxiety and fear in a large sample of genetically heterogeneous (N/Nih-HS) rats. Behav Brain Funct. 2011 Nov 25;7:48. (active avoidance, rat, Spain)
  • Vicens-Costa E et al. (2011) Two-way avoidance acquisition is negatively related to conditioned freezing and positively associated with startle reactions: A dissection of anxiety and fear in genetically heterogeneous rats. Physiology & Behavior, Volume 103, Issue 2, 3 May 2011, Pages 148–156. (active avoidance, rat, Spain)
  • Song X et al. (2012) The nuclear factor-B inhibitor pyrrolidine dithiocarbamate reduces polyinosinic-polycytidilic acid-induced immune response in pregnant rats and the behavioral defects of their adult offspring. Behav Brain Funct. 2011 Dec 31;7:50. (rat, active and passive avoidance, China)
  • Álvarez LL et al. (2010) The portacaval sham operation in rats affects acquisition but not memory of an active avoidance task. Revista iberoamericana de psicología y salud, ISSN 2171-2069, Vol. 1, Nº. 1, págs. 81-99. (rat, Spain)
  • Begega A et al. (2010) Portal hypertension in 18-month-old rats: Memory deficits and brain metabolic activity. Physiology &  Behavior, 100(2):135-142. (Active avoidance, Rat, Spain).
  • Plaza-Zabala A et al. (2010) Effects of the endogenous PPARα agonist, oleoylethanolamide on MDMAinduced cognitive deficits in mice. Synapse, Volume 64, Issue 5, pages 379–389. (active avoidance, mouse, Spain)
  • Segura-Torres P et al. (2010) Intracranial self-stimulation recovers learning and memory capacity in basolateral amygdala-damaged rats. Neurobiology of Learning and Memory, Volume 93, Issue 1, January 2010, Pages 117–126. (active avoidance, rat, Spain)
  • García-Capdevila S et al. (2009) Effects of long-term voluntary exercise on learning and memory processes: dependency of the task and level of exercise. Behavioural Brain Research, Volume 202, Issue 2, 14 September 2009, Pages 162–170. (active avoidance, Spain)
  • Dagnino-Subiabre A et al. (2009) Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning Behavioural Brain Research203(1):88-96 (rat, Chile, USA)
  • Johannesson M et al. (2009) A resource for the simultaneous high-resolution mapping ofmultiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Res. 2009 19: 150-158. (rat, Spain, Sweden, UK, USA)
  • Lopez-Aumatell R et al. (2009) Unlearned anxiety predicts learned fear: A comparison among heterogeneous rats and the Roman rat strains. Behav. Brain. Res. 202(1):92-101. (active avoidance, rat, Spain)
  • Mendez M et al. (2009) Associative learning deficit in two experimental models of hepatic encephalopathy. Behav. Brain Res. 198(2):346-351. (active and passive avoidance, rat, Spain)
  • Valverde O et al. (2009) GPR3 receptor, a novel actor in the emotional-like responses. PLoS One. 4(3):e4704. (mice, Spain, Belgium)
  • Ciamei A et al. (2008) Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease. Neurobiology of Learning and Memory, Volume 89, Issue 4, May 2008, Pages 533–544. (active avoidance, mouse, UK)
  • Lopez-Aumatell R et al. (2008) Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and females. Behavioural Brain Research, Volume 188, Issue 1, 17 March 2008, Pages 41–55. (active avoidance, rat, Spain, UK)
  • Martin-Garcia et al (2008) Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration. Neuroscience. 154(4):1497-1505 (rat, Spain)
  • Mendez et al. (2008) Associative learning deficit in two experimental models of hepatic encephalopathy. Behavioural Brain Research, Volume 198, Issue 2, 17 March 2009, Pages 346-351. (rat, Spain)
  • Rueda N et al. (2008) Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behavioural Brain Research, Volume 188, Issue 2, 9 April 2008, Pages 355-367 (mouse, Spain)
  • Ruiz-Medina J et al (2008) Intracranial self-stimulation improves memory consolidation in rats with little training. Neurobiol. Learn. Mem. 89(4):574-581 (rat, Spain)
  • Trigo JM et al (2008) MDMA modifies active avoidance learning and recall in mice. Psychopharmacol. 197:391-400 (mouse, Spain)
  • Andero R et al. (2007) Electrical stimulation of the pedunculopontine tegmental nucleus in freely moving awake rats: Time- and site-specific effects on two-way active avoidance conditioning. Neurobiol. Learn. Mem. 87(4):510-521 (rat, Spain)
  • Bura SA et al. (2007) Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes. Br J Pharmacol. 2007 March; 150(6): 758–765. (mice, Spain, Belgium)
  • Quiroz-Padilla MF et al. (2007) Effects of parafascicular excitotoxic lesions on two-way active avoidance and odor-discrimination. Neurobiol. Learn. Mem. (active avoidance, rat, Spain)
  • Lopez-Aumatell R et al. (2007) Fearfulness in a large N/Nih genetically heterogeneous rat stock: Differential profiles of timidity and defensive flight in males and females. Behav. Brain Res. 188(1):41-55 (rat, Spain)
  • Millan M et al. (2007) A preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent. III. Actions in models of therapeutic activity and induction of side-effects. J. Pharmacol. Exp. Ther. (active avoidance, rat, France)
  • Soriano-Mas C et al. (2007) Intracranial self-stimulation after memory reactivation: Immediate and late effects. Brain Res. Bull. 74(1-3):51-57 (rat, Spain)
  • Norby T et al. (2006) Posttraining epinephrine treatment reduces the need for extensive training. Physiology & Behavior, Volume 89, Issue 5, 30 December 2006, Pages 718–723. (active avoidance, rat, Spain)
  • Vicente F et al. (2006) Immunization and facilitation produced by predictable and controllable aversive events alternating with different duration unpredictable and uncontrollable aversive events. Int. J. Psychol. 41(5): 385-396. (learned heplessness, rat, spain)
  • Millan MJ et al. (2004) S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole. J. Pharmacol. Exp. Ther. (learned helplessness, rat, France, Poland, UK)
  • Montero-Pastor A et al. (2004) Effects of electrical stimulation of the nucleus basalis on two-way active avoidance acquisition, retention, and retrieval. Behavioural Brain Research, Volume 154, Issue 1, 23 September 2004, Pages 41–54. (active avoidance, rat, Spain)
  • Aguilar R et al. (2003) Fearfulness and sex in F2 Roman rats: males display more fear though both sexes share the same fearfulness traits. Physiol. Behav. 78(4-5):723-32. (fear conditioning, rat, Spain)
  • Redolar-Ripoll D et al. (2003) Posttraining intracranial self-stimulation ameliorates the detrimental effects of parafascicular thalamic lesions on active avoidance in young and aged rats. Behavioral Neuroscience, Vol 117(2), Apr 2003, 246-256. (active avoidance, rat, Spain)
  • Aguilar R et al. (2002) Learned fear, emotional reactivity and fear of heights: a factor analytic map from a large F2 intercross of roman rat strains. Brain res. Bull. 57(1):17-26. (fear conditioning, active avoidance, rat, Spain)
  • Fernandez-Teruel A et al. (2002) A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res. 1-9. (active avoidance, rat, Spain)
  • Martin M et al. (2002) Involvement of CB1 cannabinoid receptors in emotional behaviour. Psychopharmacology (Berl). 159(4):379-87. (active avoidance, mice, Spain)
  • Morón I et al. (2002) Differential effects of bicuculline and muscimol microinjections into the nucleus basalis magnocellularis in taste and place aversive memory formation. Behav. Brain Res. 134: 425-431. (rat, Spain, Mexico)
  • Tordera EM et al. (2002) Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European Journal of Pharmacology, Volume 442, Issues 1–2, 3 May 2002, Pages 63–71. (learned helplessness, rat, Spain)
  • Vale-Martinez A et al. (2002) Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats. Exp. Bran Res. 142(1): 52-66. (active avoidance, rat, Spain)
  • Oficialdegui AM et al. (2000) Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism. Il Farmaco, Volume 55, Issue 5, May 2000, Pages 345–353 (learned helplessness, Spain)
  • Rubio S et al. (1999) Active avoidance conditioning in rats: absence of sex difference and estrous effect. Psicothema 11(3): 655-661 (active avoidance, rat, Spain)
  • Tenas-Huerga N et al. (1998) Facilitatory effects of thalamic reticular nucleus lesions on two-way active avoidance in rats Experimental Brain Research, 118(4): 511-516. (active avoidance, rat, Spain)
  • Doming JL et al. (1996) Age-related effects of aluminum ingestion on brain aluminum accumulation and behavior in rats. Life Sciences, Volume 58, Issue 17, 22 March 1996, Pages 1387–1395. (rat, Spain)
  • Poncelet et al. (1995) Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. Journal of Neural Transmission / General Section JNT 1995, Volume 102, Issue 2, pp 83-90 (rat, mouse, France)
  • Prunell M et al. (1987) Antagonism of the stimulant and depressant effects of ethanol in rats by naloxone. 92(2): 215-218. (active avoidance, rat, Spain)

 

How to order

SHUTAVOID SOFTWARE 

ShutAvoid

76-0202

PC Software to control up to 8 Shuttle Boxes or Passive Avoidance Boxes


How to order

Please contact our local delegates or contact us directly for receiving a quote.

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  • Other countries: link
  • Key features

    • Allows editing protocols for both active and passive avoidance
    • Experimental chambers can be controlled independently
    • A Test mode enables immediate and reliable box checking
    • New configuration panel for Yoked procedures
    • The program runs automatically when the animal is detected in the cage
    • Animal position and current data can be visualized on-line
    • Provides integrated data
    • Re-analyses data in user-defined intervals of time

     

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    • Passive avoidance box

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