5 choice serial reaction time task

Description
Related Panlab Integrated Solutions

Description

The 5-choice serial reaction time (5CSRT) task is commonly used to evaluate attention performance using visual discrimination in laboratory animals. It represents a conditioning paradigm, involving intact attention processes.

The test was developed as a rodent homologue of the continuous performance task (CPT) for humans. In this test, the subject has to learn to respond to a brief illumination of one of the five openings, by poking its nose inside the correct hole in order to obtain a food reward. Only one hole is illuminated in each trial and in each trial every hole has the same probability of being illuminated. The duration of the visual stimulus can be varied to modulate the load on the attentional effort.

More the rules are learned by the subject, more the time spent to get the reward, as well as the number of errors are decreased. Multiple aspects of the behavior can be recorded to analyze results:

  • Percentage of correct responses
  • anticipatory responses (homologue of impulsive human behavior)
  • perseverative responses (homologue of compulsive human behavior).

These parameters gives information about the functional integrity of attentional and learning processes and are mostly altered in animal models of schizophrenia and Alzheimer diseases.

Related Panlab Integrated Solutions


5/9 HOLES BOX (Panlab) - (n) RAT

  • (n) x LE509MO 5/9 hole box (1 per rat)
  • 1 Food or drink dispenser
  • 1 x PACKWIN V2.0 software (for up to 8 boxes)
  • 1 x PACKWINHO - PACKWIN 5CSRT experimental module
  • (n) x Isolation box LE26 or LE26M (1 per box)

Additional option for the definition of protocols different from the standard 5CSRT protocol:

  • 1 x PACKWINCS - PACKWIN Customized module

 


STANDARD 5/9 HOLES BOX (Panlab) - (n) MICE

  • (n) x LE507MO box (1 per mouse)
  • 1 Food or drink dispenser
  • 1 x PACKWIN V2.0 software
  • 1 x PACKWINHO - 5CSRT experimental module
  • (n) x Isolation box (LE26 or LE26M)

Additional option for the definition of protocols different from the standard 5CSRT protocol:

  • 1 x PACKWINCS - PACKWIN Customized module

 


 

Reasons for choosing this test

  • Widely used in literature to study visual discrimination/attention
  • Allows the exploration of a wide variety of cognitive processes
  • Robust performance and specific responses

Reasons for not choosing this test

  • Classically used in rats and more recently adapted in mice
  • Long and laborious procedure
  • Requires prior food or drink deprivation
  • Changes in behavioral output can be brought by many non-cognitive factors, such as alteration of locomotor activity, vision, anxiety level…
 
 
 
 
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