Startle response to acoustic and tactile stimulus test

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The startle response is a brainstem reflex elicited by an unexpected acoustic or tactile stimulus.

The evaluation of startle reflex response (and its habituation) to acoustic or tactile stimulus of different intensities is widely used for the detection of sensorimotor gating and hearing deficiencies in phenotyping evaluations.

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Reasons for choosing this test

  • Neurological phenotyping for motor and sensory capabilities
  • Objective measurement: automated detection of startle reflex
  • Sensitive for both rats and mice

Reasons for not choosing this test

  • Restraint conditions (habituation phase needed)
  • Non-specific influence of attention processes
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