VON FREY electrónico

Para evaluar la alodinia mecánica en roedores

Puntos clave
Como pedirlo


The electronic model of Von-Frey filament combines ease of use and rapidity for the determination of the mechanical sensitivity threshold in rodent.


Basically, a tip is applied against the central edge of the animal hind paw. Paw withdrawal caused by the stimulation is registered as a response. The corresponding force applied is recorded by the system and displayed on the large backlighted screen of the Von-Frey unit with a resolution of 0.1 grams. A different tip is used for rat (hard plastic tip) and mice (elastic spring tip).

Differently to the procedure using classical Von-Frey filaments, the threshold value can be obtained in only one test, and in a highly reproducible manner. A foot-switch is proved to carry out rapid hands-free experiments.

The new Electronic Von Frey EVF4 is provided with a easier and more comfortable handle. The BIO-CIS software can be used to automatically record the results on a PC through a RS 232 port (direct Excel exportation).

Component Included

  • Stimulus handle
  • Hard (10 units) and soft (1 unit) tips for rat and mouse
  • Footswitch
  • Storage casing
  • Software (only with 750976 EVF4S)

 Stand and enclosure have to be purchased separately.



Measurement range 0 to 500 g (5N), 120% overload allowed without causing any damage to the sensor
Precision Resolution: 0.1 g; Accuracy: 0.2 g
Temperature compensation from 0 to 50°C
Statistical functions Average value and standard deviation are computed for each subject
Internal Memory up to 100 values
Power supply 220-240 V (other voltages on request)
Weight 6,5kg
BSBIOSTDEVF Dimensions (W x D x H) Mouse: 6 compartments, 11 cm x 7 cm x 14 cm each; Rat: 2 compartments, 22 x 11 x 14 cm each
BSBIOPVF Rat Dimensions 22 cm W x 11 cm D x 14 cm H


  • Dolique T et al. (2013) Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain. PAIN, Volume 154, Issue 11, Pages 2529–2546. (rat, France)
  • Jiao Y et al. (2013) Protective effect of hydrogen on diabetic peripheral neuropathy by suppressing nulcear factor-kappaB pathway. Chinese Journal of Contemporary Neurology & Neurosurgery. Vol 13, No 9 (rat, China)
  • Redondo-Castro E et al. (2013) Phagocytic microglial phenotype induced by glibenclamide improves functional recovery but worsens hyperalgesia after spinal cord injury in adult rats. European Journal of Neuroscience, In Press (rat, Spain)
  • Salat R et al. (2013) The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy. Computer Methods and Programs in Biomedicine, Volume 111, Issue 2, Pages 330–337. (mouse, Poland)
  • Salat R et al. (2013) Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, June 2013, Volume 386, Issue 6, pp 493-505 (mouse, Poland)
  • Spanevello MD et al. (2013) Acute Delivery of EphA4-Fc Improves Functional Recovery after Contusive Spinal Cord Injury in Rats. Journal of Neurotrauma. June 15, 2013, 30(12): 1023-1034. (rat, Australia)
  • Thibault K et al. (2013) Structural and Molecular Alterations of Primary Afferent Fibres in the Spinal Dorsal Horn in Vincristine-Induced Neuropathy in Rat. Journal of Molecular Neuroscience, Volume 51, Issue 3, pp 880-892 (rat, France)
  • Vera G et al. (2013) Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy. Pharmacology Biochemistry and Behavior105: 205–212 (Neuropathy, rat, Spain).
  • Ng Wing Tin S et al. (2013) Sensory correlates of pain in peripheral neuropathies. Clin Neurophysiol. 2013 Oct 28. pii: S1388-2457. (human, 2013)
  • Zengin-Toktas Y et al. (2013) Bilateral lesions of the nigrostriatal pathways are associated with chronic mechanical pain hypersensitivity in rats. Neuroscience Research, Volume 76, Issue 4, Pages 261–264 (rat, France)
  • Burgos E et al. (2012) Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells. European Journal of Pharmacology. 682(1–3): 62–72 (rat, Spain).
  • Liu MG et al. (2012) Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. J Neuroinflammation. 2012 Nov 27;9:258. (rat, Japan)
  • Lorenzini K et al. (2012) Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers. CHIMIA International Journal for Chemistry, Volume 66, Number 5, May 2012 , pp. 296-299(4). (human, Switzerlan)
  • Thibault K et al. (2012) Cortical effect of oxaliplatin associated with sustained neuropathic pain: Exacerbation of cortical activity and down-regulation of potassium channel expression in somatosensory cortex. Pain 153(8): 1636-1647. (rat, France)
  • Vera G et al. (2012) Characterisation of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes. Pharmacology Biochemistry and Behavior102(2): 335–343 (rat Spain)
  • Boretius T et al. (2011) Biocompatibility of chronically implanted transverse intrafascicular multichannel electrode (TIME) in the rat sciatic nerve. IEEE Trans Biomed Eng. 2011 Aug;58(8). (rat, Spain)
  • Castro ER et al. (2011) Longitudinal study of wind-up responses after graded spinal cord injuries in the adult rat. Restorative Neurology and Neuroscience. 29(2):115-126. (rat, Spain)
  • Favereaux A et al. (2011) Bidirectional integrative regulation of Cav1. 2 calcium channel by microRNA miR-103: role in pain. The EMBO Journal (2011) 30, 3830 – 3841. (rat, France, Egypt)
  • Lorenzini K et al. (2011) A Randomized, Controlled Trial Validates a Peripheral Supra-Additive Antihyperalgesic Effect of a Paracetamol–Ketorolac Combination. Basic & Clinical Pharmacology & Toxicology, Volume 109, Issue 5, pages 357–364. (human, Switzerland)
  • Reali C et al. (2011) Intrinsic membrane properties of spinal dorsal horn neurones modulate nociceptive information processing in vivo. J. Physiol. In press (rat, France)
  • Schwedt TJ (2011) Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia, 31(1):6-12. (human, USA)
  • Udina E et al. (2011) Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat. Muscle & Nerve, Volume 43, Issue 4, pages 500–509 (rat, Spain)
  • Fossat P et al. (2010) Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J. Neurosci. 30(3):1073-1085. (rat, neuropathy, France)
  • Okumura M et al. (2010) Alternation of Gene Expression in Trigeminal Ganglion Neurons Following Complete Freund’s Adjuvant or Capsaicin Injection into the Rat Face. Journal of Molecular Neuroscience, October 2010, Volume 42, Issue 2, pp 200-209. (rat, Japan)
  • Verron et al. (2010) Analgesic properties of calcium phosphate apatite loaded with bupivacaine on postoperative pain. J. Biomedical Materials research Part B: Applied Biomaterials. 94B(1):89-96. (rat, France)
  • Asensio-Pinilla E et al. (2009) Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury. Experimental Neurology, Volume 219, Issue 1, Pages 258–265. (rat, Spain)
  • Casals-Diaz L et al. (2009) Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Exp. Neurol. 217(1):84-95. (rat, Spain)
  • Duale C et al. (2008) Cutaneous Amitriptyline in Human Volunteers: Differential Effects on the Components of Sensory Information. Anesthesiology. 108(4):714-721 (human, France)
  • Laalou FZ et al (2008) Involvement of the Basal Cholinergic Forebrain in the Mediation of General (Propofol) AnesthesiaAnesthesiology. 108(5):888-896 (Rat, France)
  • Lefaucheur JP et al (2008) Motor cortex rTMS in chronic neuropathic pain: pain relief is associated with thermal sensory perception improvement. J Neurol Neurosurg Psychiatry. 79(9):1044-9 (human, France)
  • Thibault K et al. (2008) Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine. Eur. J. Pharmacol. 600(1-3):71-77. (rat, France)
  • Vivó M et al. (2008) Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair. Exp. Neurol. 211(1):180-193 (Rat, Spain)
  • Pickering G et al. (2007) Acetaminophen reinforces descending inhibitory pain pathways. Clin. Pharmacol. Ther. 84(1):47-51. (human, France)
  • Chassaing C et al. (2006) Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers. Br. J. Clin. Pharmacol. 61(4): 389. (Human, France)
  • Benani A et al. (2003) Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Eur. J. Neurosci. 18(7): 1904. (Rat, France)
  • Wiesenfeld-Hallin Z et al. (2002) Large-amplitude 5-HT< sub> 1A</sub> receptor activation: a new mechanism of profound, central analgesia. Neuropharmacology, Volume 43, Issue 6, Pages 945–958. (rat, France, Sweden)


Como pedirlo




Electronic Von Frey EVF4S package complete with hard and soft tips, footswitch, casing and software



Electronic Von Frey EVF4 basic with hard and soft tips, footswitch and casing (without software)



BIOCIS Force Ramp Software





Robust animal enclosure for 2 rats or 6 mice  for VF stand  or heargreaves test



Elevated stand with metal mesh, delivered  without cage fit up to 3 BIO-PVF



Patient switch for clinical research protocols (needed for clinical units)





Hard plastic tips, 10 units



Elastic (spring) tips, 1 unit



Tips Replacement Box (10 Hard Plastic tips, 1 Spring tip, and 3 Dust Disks)


Cómo pedir una orferta

Contacta nuestro distribuidor el más cercano o contáctanos directamente para recibir una oferta.


Puntos clave

  • NEW easier and more comfortable handle
  • Provides objective and accurate data
  • The threshold value can be obtained in only one test, and in a highly reproducible manner
  • Elimination of the problems of filament standardization
  • Stimulation of areas of equal size
  • The end-point value is automatically recorded
  • Real time force curves in BIOCIS software


Tests relacionados

Von Frey test

Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continúa navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información en nuestra Política de Cookies.