ELECTRONIC VON FREY

For evaluating mechanical allodynia in rodents

Description
Key features
Specs
How to order
Publications

Description

NEW! A new version of the Electronic Von Frey with embedded video (EVF5)

The electronic model of Von Frey filament combines ease of use and rapidity for the determination of the mechanical sensitivity threshold in rodent.

Description

The Von Frey filament is applied against the central edge of the animal hind paw. Paw withdrawal caused by the stimulation is registered as a response. The corresponding force applied is recorded by the system and displayed on the large backlighted screen of the Von Frey unit with a resolution of 0.1 grams. A different tip is used for rat (hard plastic tip) and mice (elastic spring tip).

The Electronic Von Frey EVF4 and EVF5 are equipped with batteries. It allows performing measurement for several hours without connection to power supply.

Differently to the procedure using classical Von-Frey filaments, the threshold value can be obtained in only one test, and in a highly reproducible manner. The electronic instrument does not present any temperature or hygrometry drift, which used to be an issue with the manual version of the filaments.

Electronic Von Frey 4

The Electronic Von Frey EVF4 is provided with a easier and more comfortable handle (when compared to the EVF3 version).

The BIO-CIS software can be used to automatically record the results on a PC through a RS 232 port (direct Excel exportation). The BIO-CIS software can also be used for increasing the repeatability of nociceptive tests: while recording the reflex respond the software help the operator to improve his skills with the instrument, as well as to invalidate off-limit results. A brand new function also allows you to import all data from a wide range of instruments directly into Excel for further analysis!

Two packages are available: EVF4 (without software) and EVF4S (including the software).

Component included

  • Control unit
  • Stimulus handle
  • Hard (10 units) and soft (1 unit) tips for rat and mouse
  • Dusk protection disk
  • Footswitch
  • Storage casing
  • BIO-CIS Software (only included in 750976 EVF4S)

Stand and enclosure have to be purchased separately.

 

Electronic Von Frey 5

The new Electronic Von Frey EVF5 version provides an embedded camera mounted on the handle in order to make easier the visualization of the point of stimulation.

The brand new BIOEVF software comes with a lot of new features :

  • Video with target pointer: No more stretching to target the paw
  • Real-time curve display: immediate display of applied force, which helps for replicable measures
  • Value assignation to each animal's paw: Special feature for touch screen PC ! Validation in 1 touch (or 1 click)

Two packages are available: EVF5 and EVF5Tablet

Component included

  • Control unit
  • Stimulus handle mounted with a camera
  • Hard (10 units) and soft (1 unit) tips for rat and mouse
  • Dusk protection disk
  • Footswitch
  • Storage casing
  • BIOEVF Software
  • Tablet (only included in 750978 EVF5-TABLET)

Stand and enclosure have to be purchased separately.

Specs

Measurement range 0 to 500 g (5N), 120% overload allowed without causing any damage to the sensor
Precision Resolution: 0.1 g; Accuracy: 0.2 g
Temperature compensation from 0 to 50°C
Statistical functions Average value and standard deviation are computed for each subject
Internal Memory up to 100 values
Power supply 220-240 V (other voltages on request)
Weight 6,5kg

Publications

  • Dolique T et al. (2013) Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain. PAIN, Volume 154, Issue 11, Pages 2529–2546. (rat, France)
  • Jiao Y et al. (2013) Protective effect of hydrogen on diabetic peripheral neuropathy by suppressing nulcear factor-kappaB pathway. Chinese Journal of Contemporary Neurology & Neurosurgery. Vol 13, No 9 (rat, China)
  • Redondo-Castro E et al. (2013) Phagocytic microglial phenotype induced by glibenclamide improves functional recovery but worsens hyperalgesia after spinal cord injury in adult rats. European Journal of Neuroscience, In Press (rat, Spain)
  • Salat R et al. (2013) The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy. Computer Methods and Programs in Biomedicine, Volume 111, Issue 2, Pages 330–337. (mouse, Poland)
  • Salat R et al. (2013) Evaluation of antinociceptive and antioxidant properties of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, June 2013, Volume 386, Issue 6, pp 493-505 (mouse, Poland)
  • Spanevello MD et al. (2013) Acute Delivery of EphA4-Fc Improves Functional Recovery after Contusive Spinal Cord Injury in Rats. Journal of Neurotrauma. June 15, 2013, 30(12): 1023-1034. (rat, Australia)
  • Thibault K et al. (2013) Structural and Molecular Alterations of Primary Afferent Fibres in the Spinal Dorsal Horn in Vincristine-Induced Neuropathy in Rat. Journal of Molecular Neuroscience, Volume 51, Issue 3, pp 880-892 (rat, France)
  • Vera G et al. (2013) Characterization of cannabinoid-induced relief of neuropathic pain in a rat model of cisplatin-induced neuropathy. Pharmacology Biochemistry and Behavior105: 205–212 (Neuropathy, rat, Spain).
  • Ng Wing Tin S et al. (2013) Sensory correlates of pain in peripheral neuropathies. Clin Neurophysiol. 2013 Oct 28. pii: S1388-2457. (human, 2013)
  • Zengin-Toktas Y et al. (2013) Bilateral lesions of the nigrostriatal pathways are associated with chronic mechanical pain hypersensitivity in rats. Neuroscience Research, Volume 76, Issue 4, Pages 261–264 (rat, France)
  • Burgos E et al. (2012) Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells. European Journal of Pharmacology. 682(1–3): 62–72 (rat, Spain).
  • Liu MG et al. (2012) Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. J Neuroinflammation. 2012 Nov 27;9:258. (rat, Japan)
  • Lorenzini K et al. (2012) Validation of the Simplified UVB Model to Assess the Pharmacodynamics of Analgesics in Healthy Human Volunteers. CHIMIA International Journal for Chemistry, Volume 66, Number 5, May 2012 , pp. 296-299(4). (human, Switzerlan)
  • Thibault K et al. (2012) Cortical effect of oxaliplatin associated with sustained neuropathic pain: Exacerbation of cortical activity and down-regulation of potassium channel expression in somatosensory cortex. Pain 153(8): 1636-1647. (rat, France)
  • Vera G et al. (2012) Characterisation of cannabinoid-induced relief of neuropathic pain in rat models of type 1 and type 2 diabetes. Pharmacology Biochemistry and Behavior102(2): 335–343 (rat Spain)
  • Boretius T et al. (2011) Biocompatibility of chronically implanted transverse intrafascicular multichannel electrode (TIME) in the rat sciatic nerve. IEEE Trans Biomed Eng. 2011 Aug;58(8). (rat, Spain)
  • Castro ER et al. (2011) Longitudinal study of wind-up responses after graded spinal cord injuries in the adult rat. Restorative Neurology and Neuroscience. 29(2):115-126. (rat, Spain)
  • Favereaux A et al. (2011) Bidirectional integrative regulation of Cav1. 2 calcium channel by microRNA miR-103: role in pain. The EMBO Journal (2011) 30, 3830 – 3841. (rat, France, Egypt)
  • Lorenzini K et al. (2011) A Randomized, Controlled Trial Validates a Peripheral Supra-Additive Antihyperalgesic Effect of a Paracetamol–Ketorolac Combination. Basic & Clinical Pharmacology & Toxicology, Volume 109, Issue 5, pages 357–364. (human, Switzerland)
  • Reali C et al. (2011) Intrinsic membrane properties of spinal dorsal horn neurones modulate nociceptive information processing in vivo. J. Physiol. In press (rat, France)
  • Schwedt TJ (2011) Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia, 31(1):6-12. (human, USA)
  • Udina E et al. (2011) Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat. Muscle & Nerve, Volume 43, Issue 4, pages 500–509 (rat, Spain)
  • Fossat P et al. (2010) Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J. Neurosci. 30(3):1073-1085. (rat, neuropathy, France)
  • Okumura M et al. (2010) Alternation of Gene Expression in Trigeminal Ganglion Neurons Following Complete Freund’s Adjuvant or Capsaicin Injection into the Rat Face. Journal of Molecular Neuroscience, October 2010, Volume 42, Issue 2, pp 200-209. (rat, Japan)
  • Verron et al. (2010) Analgesic properties of calcium phosphate apatite loaded with bupivacaine on postoperative pain. J. Biomedical Materials research Part B: Applied Biomaterials. 94B(1):89-96. (rat, France)
  • Asensio-Pinilla E et al. (2009) Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury. Experimental Neurology, Volume 219, Issue 1, Pages 258–265. (rat, Spain)
  • Casals-Diaz L et al. (2009) Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Exp. Neurol. 217(1):84-95. (rat, Spain)
  • Duale C et al. (2008) Cutaneous Amitriptyline in Human Volunteers: Differential Effects on the Components of Sensory Information. Anesthesiology. 108(4):714-721 (human, France)
  • Laalou FZ et al (2008) Involvement of the Basal Cholinergic Forebrain in the Mediation of General (Propofol) AnesthesiaAnesthesiology. 108(5):888-896 (Rat, France)
  • Lefaucheur JP et al (2008) Motor cortex rTMS in chronic neuropathic pain: pain relief is associated with thermal sensory perception improvement. J Neurol Neurosurg Psychiatry. 79(9):1044-9 (human, France)
  • Thibault K et al. (2008) Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine. Eur. J. Pharmacol. 600(1-3):71-77. (rat, France)
  • Vivó M et al. (2008) Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair. Exp. Neurol. 211(1):180-193 (Rat, Spain)
  • Pickering G et al. (2007) Acetaminophen reinforces descending inhibitory pain pathways. Clin. Pharmacol. Ther. 84(1):47-51. (human, France)
  • Chassaing C et al. (2006) Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers. Br. J. Clin. Pharmacol. 61(4): 389. (Human, France)
  • Benani A et al. (2003) Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation. Eur. J. Neurosci. 18(7): 1904. (Rat, France)
  • Wiesenfeld-Hallin Z et al. (2002) Large-amplitude 5-HT< sub> 1A</sub> receptor activation: a new mechanism of profound, central analgesia. Neuropharmacology, Volume 43, Issue 6, Pages 945–958. (rat, France, Sweden)

 

How to order

ELECTRONIC VON FREY EVF4

SYSTEMS

BSBIOEVF4S

76-0976

Electronic Von Frey EVF4S package complete with hard and soft tips, footswitch, casing and software

BSBIOEVF4

 

76-0975

Electronic Von Frey EVF4 basic with hard and soft tips, footswitch and casing (without software)

BSBIOCIS

76-0741

BIOCIS Force Ramp Software (option for BSBIOEVF4)

 

ELECTRONIC VON FREY EVF5

SYSTEMS

BSBIOEVF5

76-0977

Electronic Von Frey EVF5, 0-500g, with Video Camera, incl. Analysis software

BSBIOEVF5TABLET

 

76-0978

Electronic Von frey EVF5, 0-500g, with Video Camera, Tactile tablet PC, incl. Analysis software

 

EVF4 AND EVF5 ACCESSORIES

BSBIOPVF

760788

Robust animal enclosure for 2 rats or 6 mice  for VF stand  or heargreaves test

BSBIOSTDEVF

760789

Elevated stand with metal mesh, delivered  without cage fit up to 2 BIO-PVF

BSBIOEVF2PS10

760636

Patient switch for clinical research protocols (needed for clinical units)

 

SPARE PARTS 

BSBIOEVFD

76-0488

Hard plastic tips, 10 units

BSBIOEVFRS

76-0489

Elastic (spring) tips, 1 unit

 

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • NEW embedded Video option
  • Easy-to-use/Ergonomic Handle
  • Provides objective and accurate data
  • The threshold value can be obtained in only one test, and in a highly reproducible manner
  • Elimination of the problems of filament standardization
  • Stimulation of areas of equal size
  • The end-point value is automatically recorded
  • Real time force curves(by software)

 

Related tests

Von Frey test

 
 
 
 
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