IR ACTIMETER

for locomotor activity, exploration and anxiety

Description
Key features
Specs
How to order
Publications

Description

The Panlab Infrared (IR) Actimeter allows the study of spontaneous locomotor activity, rearings and optionally hole-board test parameters for exploration in rodents. A reliable system for easy and rapid drug screening and phenotype characterisation in both day and night lighting conditions. 

The system is basically composed by a 2 dimensional (X and Y axes) square frame, a frame support and a control unit. Each frame counts with 16 x 16 infrared beams for optimal subject detection.

The system is completely modular: each frame may be used for evaluation of general activity (one or several animals), locomotor and stereotyped movements or rearings or exploration (nose-spoke detection in the hole-board option). The infrared photocell system can be set with up to 15 levels of sensitivity in order to adapt the frames to the typology of the animal (rats, mice). It can also be set to ignore the beams that are obstructed by objects (e.g. the walls/corners of the home cage).

The frames can be controlled by the independent control units LE8825 or directly through the optional SEDACOM computer software. The new SEDACOM 2.0 version provides an easy and convenient way to visualize and export the data on a computer for further analysis. 

Optionally, the ActiTrack software option may be used to analyse animal trajectories (distance, speed, permanence time in selected zones) and then provide additional complementary data to those obtained using the control units.

 

Specs

IR Frame Dimensions LE 8815 (internal) 450 (W) x 450 (D) x 200 (H) mm
IR Frame Dimensions LE 8816 (internal) 250 (W) x 250 (D) x 200 (H) mm
Number of InfraRed Beams per Frame 32 (16 per axis)
InfraRed Photocells Spacing 25mm (LE8815); 13mm (LE8816)
Material Composition Aluminium, Polipropilene
Maximum number of stations 32 InfraRed Frames per computer (either SeDaCom or ActiTrack)
Power Requirements 110/220 V, 50/60 Hz
Certifications CE Compliant

Publications

  • Abedi PM et al. (2013) Intrapallidal administration of 6-hydroxydopamine mimics in large part the electrophysiological and behavioral consequences of major dopamine depletion in the rat. Neuroscience. Volume 236, 16 April 2013, Pages 289–297 (rat, France, Marocco)
  • Carrasco P et al. (2013) Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behavioural Brain Research, Volume 256, 291–297. (mouse, Spain)
  • Casarejos MJ et al. (2013) Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy. Journal of Alzheimer's Disease, Volume 35, Number 3: 525-539. (mouse, Spain)
  • Chetrit J et al. (2013) Inhibiting Subthalamic D5 Receptor Constitutive Activity Alleviates Abnormal Electrical Activity and Reverses Motor Impairment in a Rat Model of Parkinson's Disease. The Journal of Neuroscience, 33(37): 14840-14849 (rat, France).
  • Garcia-Rios RI et al. (2013) Anxiolytic-Like Actions of Fatty Acids Identified in Human Amniotic Fluid. The Scientific World Journal. Volume 2013 (2013), Article ID 823289, 6 pages. (rat, mexico)
  • Llorente-Foch I et al. (2013) AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway. Journal of Neurochemistry. Volume 124, Issue 3, pages 347–362. (mice, Spain, Japan)
  • Lutz PE et al. (2013) A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice. Behavioural Brain Research, Volume 243, 15 April 2013, Pages 44–52. (mice, Canada, France)
  • Mantha K et al. (2013) Neurodevelopmental Timing of Ethanol Exposure May Contribute to Observed Heterogeneity of Behavioral Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorder (FASD). Journal of Behavioral and Brain Science, 2013, 3, 85-99. (mouse, Canada)
  • Rodríguez-Landa JF (2013) Participation of GABAA Chloride Channels in the Anxiolytic-Like Effects of a Fatty Acid Mixture. BioMed Research International, Article ID 121794. (rat, Mexico)
  • Nobrega C et al. (2013) Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice. PLoS ONE 8(1): e52396. doi:10.1371/journal.pone.0052396. (mouse, Portugal).
  • Shin JC et al. (2013) The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase. Biochemical and Biophysical Research Communications. Volume 440, Issue 2, 18 October 2013, Pages 312–316. (rat, South Korea).
  • Delaville C et al. (2013) Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing. Neurobiology of Disease. Volume 47, Issue 3, September 2012, Pages 322–330. (rat, France)
  • Busquets S et al. (2012) Myostatin blockage using actRIIB antagonism in mice bearing the Lewis lung carcinoma results in the improvement of muscle wasting and physical performance. Journal of Cachexia, Sarcopenia and Muscle, Volume 3, Issue 1, pp 37-43. (Spain, USA)
  • Diaz-Alonso J et al. (2012) The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis. The Journal of Neuroscience, 32(47): 16651-16665 (mice, Spain, Germany, UK)
  • Laloux C et al. (2012) Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease. Pharmacological Research, Volume 65, Issue 5, Pages 514–522. (mouse, France)
  • Lesmana R et al. (2012) Lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor. Environmental Toxicology. (rat, Japan, Indonesia)
  • Nasir MN et al. (2012) Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synapticpotential and locomotor activity. Phytomedicine, Volume 19, Issues 3–4, Pages 311–316. (rat, Malaysia, Germany)
  • Sabbar et al. (2012) Lead intoxication induces noradrenaline depletion, motor nonmotor disabilities, and changes in the firing pattern of subthalamic nucleus neurons. Neuroscience Volume 210, 17 May 2012, Pages 375–383. (rat, France)
  • Varani AP et al. (2012) Acute behavioural responses to nicotine and nicotine withdrawal syndrome are modified in GABAB1 knockout mice. Neuropharmacology, Volume 63, Issue 5, Pages 863–872 (mouse, Argentina, Switzerland)
  • Blazquez C et al. (2011) Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease. Brain 134 (1): 119-136. (mouse, Spain)
  • Garcia C et al (2011) Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease. British Journal of Pharmacology. Volume 163, Issue 7, pages 1495–1506 (rat, Spain, UK)
  • Kleiber et al. (2011) Maternal voluntary drinking in C57BL/6J mice: Advancing a model for fetal alcohol spectrum disorders. Behavioural Brain Research. Volume 223, Issue 2, 1 October 2011, Pages 376–387. (mouse, Canada)
  • Marche K et al. (2011) Fetal alcohol-induced hyperactivity is reversed by treatment with the PPARα agonist fenofibrate in a rat model. Psychopharmacology, Volume 214, Issue 1, pp 285-296 (rat, France)
  • Penna F et al. (2011) Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise. Journal of Cachexia, Sarcopenia and Muscle, June 2011, Volume 2, Issue 2, pp 95-104. (Italy, Spain)
  • Pugsley MK et al. (2011) Innovation in safety pharmacology testing. Journal of Pharmacological and Toxicological Methods, Volume 64, Issue 1, Pages 1–6 (USA, Belgium, Canada, UK)
  • Ishihama T et al. (2010) Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice. Behav. Brain Res. 209(2):274-280. (Mice, Japan).
  • Perucho J et al. (2010) Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer's disease.J. Alzheimer’s Disease. 19(4): 1245-57. (Mouse, Spain)
  • Rodríguez-Navarro JA et al. (2010) Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiology of Disease, Volume 39, Issue 3, Pages 423–438. (mouse, Spain, USA)
  • Chetrit J et al. (2009) Involvement of Basal Ganglia Network in Motor Disabilities Induced by Typical Antipsychotics. PLoS One. 2009 Jul 9;4(7):e6208. (rat, France)
  • Canini F et al. (2009) Metyrapone decreases locomotion acutely. Neurosci. Letters. 457(1):41-44. (locomotion, rat, France)
  • Chetrit J et al. (2009) Involvement of Basal Ganglia Network in Motor Disabilities Induced by Typical Antipsychotics. PLoS One. 4(7):e6208. (Open-field with Actitrack, rat, France).
  • Lamberty Y et al. (2009) Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice. Behav. Brain Res. 198(2):329-333. (mouse, Belgium)
  • Lopez-Aumatell R et al. (2009) Unlearned anxiety predicts learned fear: A comparison among heterogeneous rats and the Roman rat Straits. Behavioural Brain Research, 202: 92-101. (Spontaneous activity, rats, Spain, UK, Switzerland)
  • Tsuchida R et al. (2009) An Antihyperkinetic Action by the Serotonin 1A–Receptor Agonist Osemozotan Co-administered With Psychostimulants or the Non-stimulant Atomoxetine in Mice. J. Pharmacological Sci. 109(3):396-402. (locomotion, mouse, Japan)
  • Goeldner C et al. (2008) Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus. J Neurosci., 28(9):2190 –2198. (object-recognition test, mouse, France)
  • Lalonde R and Strazielle (2008) Exploratory activity and motor coordination in old versus middle-aged C57BL/6J mice. Arch Gerontol Geriatr. 2009 Jul-Aug;49(1):39-42.(Locomotor activity, mouse, Canada)
  • Lalonde R and Strazielle (2008) Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice. J: Neurosci. Meth. 171(1):48-52 (Locomotor activity, mouse, Canada)
  • Lalonde R et al. (2008) Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice. Brain Res. 1188:122-131 (open field, mouse, Canada)
  • Le Pen G et al. (2008) Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. Parkinsonism Relat Disord. 14 Suppl 2:S107-11. (mouse, France)
  • Rubio M (2008) CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. Neuropharmacology. 54(6):976-988 (rat, Spain, USA)
  • Pioli EY et al. (2008) Differential behavioral effects of partial bilateral lesions of ventral tegmental area or substantia nigra pars compacta in rats. Neurosci. 153(4):1213-1224. (rat, France, Germany)
  • Rubio M (2008) CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. Neuropharmacology. 54(6):976-988. (rat, Spain, USA)
  • Belujon P et al (2007) Noradrenergic Modulation of Subthalamic Nucleus Activity: Behavioral and Electrophysiological Evidence in Intact and 6-Hydroxydopamine-Lesioned Rats. J Neurosci. 27(36):9595-9606. (Parkison rats, France)
  • Reiss D et al (2007) Effects of social crowding on emotionality and expression of hippocampal nociceptin/orphanin FQ system transcripts in mice. Behav. Brain Res. 184(2):167-173 (mouse, France)
  • Sonnier L et al. (2007) Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1. J Neurosci. 27(5): 1063-1071. (mouse, France)
  • Andrieu D et al. (2006) Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 6:56. (mouse, France)
  • Camarasa J, Pubill D, Escubedo E (2006) Association of caffeine to MDMA does not increase antinociception by potentiates adverse effects of this recreational drug. Brain Res. 1111:72-82. (mouse, Spain)
  • Bertaina-Anglade V et al. (2006) Antidepressant properties of rotigotine in experimental models of depression. European Journal of Pharmacology, Volume 548, Issues 1–3, Pages 106–114 (rat, France, Germany)
  • González S et al. (2006) Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. Brain Research, Volumes 1073–1074, Pages 209–219. (rat, Spain)
  • Kucerova J et al. (2006) Gender differences in cannabinoid and ecstasy interacting effects in mice. Homeostasis in health and diseases. 2006(1-2): 95-96. (mouse, Czech Republic)
  • Menendez J et al. (2006) Suppression of Parkin enhances nigrostriatal and motor neuron lesion in mice over-expressing human-mutated tau protein. Human Molecular Genetics. 15(13): 2045-2058. (mouse, Spain)
  • Simonin Y et al. (2006) An Inhibitor of Serine Proteases, Neuroserpin, Acts as a Neuroprotective Agent in a Mouse Model of Neurodegenerative Disease. J. Neurosci. 26(41):10614-10619. (Mouse, Switzerland)
  • Besson V et al. (2005) Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1. Biol. Cell 97(10):787-798. (open-field, mice, France)
  • Cabranes A et al. (2005) Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. Neurobiol. Dis. 20(2):207-217. (rat, Spain)
  • Diguet E, Fernagut PO, Scherfler C, Wenning G, Tison F (2005) Effects of riluzole on combined MPTP +3-nitropropionic acid-induced mild to moderate stiatonigral degeneration in mice. J. Neural. Transm. 112(5): 613-631. (mice, France)
  • Escubedo E et al. (2005) Methyllycaconitine Prevents Methamphetamine-Induced Effects in Mouse Striatum: Involvement of _7 Nicotinic Receptors. J. Pharmacol. Exp. Ther. 315:658-667. (mouse, Spain).
  • Fan W et al. (2005) Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion, Diabetes 54:1000-1008 (Mouse, Japan)
  • González S et al. (2005) Cannabinoid CB1 receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice. Brain Research, Volume 1046, Issues 1–2, Pages 195–206. (mouse, Spain)
  • Grillet N et al. (2005) Generation and characterization of Rgs4 mutant mice. Mol. Cell. Biol. 25(10) 4221-4228. (mouse, France)
  • Arai Y-CP et al. (2004) Pre-anesthetic maternal separation increases pups' locomotor behavior during emergence from anesthesia in rats. Acta Anaesthesiol. Scand. 48(2):174. (rat, USA)
  • De Lago E et al. (2004) In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. European Journal of Pharmacology, Volume 484, Issues 2–3, Pages 249–257. (rat, Spain, Italy, UK)
  • Diguet E et al. (2004) Deleterious effects of minocycline in animal models of Parkinson’s disease and Huntington’s disease. Eur. J. Neurosci. 19(12): 3266. (mice, France)
  • Naassila M et al. (2004) Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice. Neuropharm. 46:243-253. (Mouse, France)
  • Landa L, Pistoveakova J, Suleova A (2003) Behavioural cannabinoid cross-sensitization to the effect of methamphetamine on exploratory/locomotor behaviour in mice. Journal of Prevention, Treatment and Research of addictions (Adiktologie) 2003/III/II, p5. (activity, mice, Czech Republic)
  • Aguilar R et al. (2002) Learned fear, emotional reactivity and fear of heights: a factor analytic map from a large F2 intercross of roman rat strains. Brain res. Bull. 57(1):17-26. (Rat, Spain)
  • Fernandez-Teruel A et al. (2002) A quantitative trait locus infuencing anxiety in the laboratory rat. Genome Res. 1-9. (Mouse, Spain)
  • Martínez-Cué C et al. (2002) Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav. Brain Res. 134:185-200. (Mouse, Spain)
  • Ferrari R. et al. (2001) Acute and long-term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injection. Eur. J. Neurosci. 15:1810-1818. (rat, France)
  • Ralph RJ et al. (2001) Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J. Neurosci. 21(1):305-313. (Mouse, USA)
  • Simón VM et al (2000) Predicting how equipotent doses of chlorpromazine, haloperidol, sulpiride, raclopride and clozapine reduce locomotor activity in mice. Eur. Neuropsychopharmacol. 10(3): 159-164. (Mouse, Spain)
  • Perez-Garcia C et al. (1999) Effects of histamine H3 receptor ligands in experimental models of anxiety and depression. Psychopharmacol. 142(2):215-220. (Rat, Spain)
  • Tarín JJ et al. (1999) Long-term effects of postovulatory aging of mouse oocytes on offspring: a two-generational study. Biol. of Reproduction 61:1347-1355. (Mouse, Spain)
  • Merlos M et al. (1997) Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). JPET 280(1):114-121. (Mouse, Spain)
  • Castiella E et al. (1990) Neuropharmacological activity of Prunus spinosa stem extract in mice. Phytotherapy Research, Volume 4, Issue 3, pages 101–105. (mouse, Spain)
  • Velasco A et al. (1988) Plasma Corticosterone, Motor Activity and Metabolic Circadian Patterns in Streptozotocin-Induced Diabetic Rats. Chronobiology International. Vol. 5, No. 2 , Pages 127-135. (rat, Spain)
  • Cabo J et al (1987) A pharmacological study of Glaucium flavum Crantz II: Central nervous system. Phytotherapy Research, Volume 1, Issue 4, pages 169–172. (Spain)

 

 

How to order

IR FRAMES and SUPPORTS

LE8815

76-0127

IR Frame for Rats and normal Mice, 45 x 45 cm, XY axis, 16 x 16 IR beams, 2.5 cm spaced beams.

LE8816

76-0128

IR Frame for small mice, 25 x 25 cm, XY axis, 16 x 16 IR beams, 1.3 cm spaced beams.

LE8817

76-0131

Support for LE 8815 frames.

LE8818

76-0132

Support for LE 8816 frames.

  

CONTROL UNIT (1 for each 2 IR frames)

LE8825

76-0134

Data Logger (up to 200 hours memory, RS232 comm).

  

ENCLOSURES

LE8814

76-0129

Transparent arena for 1 subject (4 walls for LE 8815), 440 x 440 mm (Open Field).

LE8813

76-0130

Transparent arena for 1 subject (4 walls for LE 8816), 210 x 210 mm (Open Field).

LE8821

76-0125

Transparent arena for 2 subjects (4 walls + divider for LE 8815), needs ActiTrack software.

LE8823

76-0126

Transparent arena for 2 subjects (4 walls + divider for LE 8816), needs ActiTrack software.

 

HOLE-BOARD ACCESSORY

LE8820

76-0133

Nose-Poke Base for LE 8815 Frame (16 holes, 2.4 diam., 1 cm depth).

 

SEDACOM OPTION FOR DEVICE CONTROL & DATA TRANSFER

SEDACOM V2.0

76-0406

SeDaCom V2.0 software for data transfer to a computer.

CONRS232USB

76-0608

SeDaCom accessory - RS232/USB adapter.

 

ACTITRACK OPTION FOR TRACKING 

ACTITRACK V2.7

76-0003

ACTITRACK Tracking Software for up to 32 frames.

ACTITRACKUPG V2.7

76-0610

Upgrade from previous version to ACTITRACK V2.7.

How to order

Please contact our local delegates or contact us directly for receiving a quote.

 

Key features

  • Minimum maintenance required
  • Minimum lighting conditions required
  • Interchangeable frames can be used without distinction for either REAR, ACT or POKING modes
  • Can be used without any computer (independent control units)

 

 
 
 
 
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