Complete solution for assessing respiratory metabolism in treadmill studies

Key features
How to order


The OxyletPro system is a modular system allowing the integration of respiratory metabolism (O2 consumption /CO2 production). Panlab provides a complete Oxylet solution enabling forced exercise training in a treadmill combined with indirect calorimetry in rodents.

Basically, Panlab Treadmill apparatus consists of a rolling belt with adjustable speed (up to 150 cm/s) and slope (from -25 to 25 degrees) and a control Unit. The rolling belt is built with especially selected materials to guarantee the best performance under conditions of intensive use and the minimum operations of maintenance, as well as simplicity in keeping it clean. The lanes (corridors of activity for the animal) have sufficient width for the subject to correct its errors in coordination, thereby allowing an exact measurement of the fatigue without deficiencies in motor coordination. 

The treadmill unit controls the speed of the belt, shows measured data in its touchscreen display and provides electrical shock to the grid. The electrical shock supplied by the grid is of constant intensity (from 0 to 2 mA), that is, the current which circulates through the animal (and therefore its effect) only depends on the value of the mA chosen and not of the subject (quantity of body mass in contact with the bars, perspiration, etc.)

For metabolism studies, the treadmill is provided with an air isolated enclosure. The LE400 air flow control unit allows a fine regulation of the air flow inside the treadmill and sends the air to the LE450 gas analyzer for O2/CO2 gas concentrations determination.

The associated METABOLISM software transfers the data from the treadmill control unit and the gas analyzer to a PC computer using RS232/USB outputs for data storage and further analysis.

NOTE: the calibration tanks are not provided with the system and should be purchased separately by the user (see Specifications tab).




Current Range adjustable from 0 to 2 mA
Belt Speed adjustable from 0 to 150cms/sec
Running Lanes 1
Slope adjustable from -25° to 25°
Exercise Area Dimensions (cm) 53 (l) x 10 (w) x 15 (h)
Treadmill Dimensions - without lid (cm) 65 (l) x 17 (w) x 24 (h)
Base/Foot Dimensions (cm) 40 (l) x 33 (w)


LE405 Oxygen Sensor

Technology Laser Diode Absorption
Measurement Range 0-100% (only limited by the hogh calibration point used)
Resolution 0.01%
Linearity +/- 0.2%
Noise +/- 0.03% (20 ms avg.)
Accuracy +/- 0.2% (24 hours)


LE405 Carbon Dioxide Sensor

Technology InfraRed Spectroscopy
Measurement range 0-10%
Resolution 0.01%
Accuracy < 10% of reading between 5%-10% CO2; < 0.3% absolute fro reading < 5% CO2
L405 Dimensions 260 (W) x 330 (D) x 120 (H) mm
LE405 Digital output RS232 (Serial port)/USB
LE405 Analogic Signal Outputs Connectors: Panel BNC female; Output O2: 10 mV/%O2; Range O2: 0-1V; Output CO2: 100 mV+(100 mV/%CO2); Range CO2: 0.1-1 V
Gas calibration Tanks needed (not provided by Panlab) Low point calibration (O2-20%, N2-80%) + High point (O2-50%, CO2-1,5%, N2-48,5%), 10 litres vol., calibration certificate needed, 150 bar pressure, stem output diam. 6 mm inner, 2 pressure regulator 3 bar each.


LE400FL Air flow and switching unit

LE400FL Air Flow 0 to 20 l/min


Room specifications for indirect calorimetry

Room temperature 20-28 °C, the important is that the temperature is maintained stable throughout the experiment.
Ventilation 10-20 room air exchanges per hour
Humidity 30-70 %Rh, the important is that the humidity is maintained stable throughout the experiment.
Barometric pressure The important is that the barometric pressure is maintained stable throughout the experiment.
Room access Dedicated closed space with controlled and reduced access to the staff







  • Freitas DA et al (2018) High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats. Physiol Behav. 2018 Feb 1;184:6-11. (VO2max, rat, Brazil)
  • Picoli CC et al. (2018) Peak Velocity as an Alternative Method for Training Prescription in Mice. Front Physiol. 2018 Feb 6;9:42. (VO2max, mouse, Brazil)
  • Teixeira-Coelho F et al. (2018) Effects of manipulating the duration and intensity of aerobic training sessions on the physical performance of rats. PLoS One. 2017 Aug 25;12(8):e0183763. (VO2max, rat, Brazil)
  • Paula FMM et al. (2017) Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis. FASEB J. 2018 Mar;32(3):1524-1536. (VO2max, mouse, Belgium, Brazil, Italy)
  • Paes LS et al. (2016) Oxygen uptake, respiratory exchange ratio, or total distance: a comparison of methods to equalize exercise volume in Wistar rats. Braz J Med Biol Res. 2016 Jul 28;49(8). (VO2max, rat, Brazil)
  • Kurauti MA et al. (2016) Acute exercise restores insulin clearance in diet-induced obese mice. J Endocrinol. 2016 Jun;229(3):221-32. (Treadmill Oxylet, VO2max, mouse, Brazil)
  • Costa Júnior JM et al. (2015) Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice. Amino Acids. 2015 Apr;47(4):745-55. (Treadmill Oxylet, VO2max, mouse, Brazil)
  • Paula FM et al. (2015) Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling. FASEB J. 2015 May;29(5):1805-16. (Treadmill Oxylet, mouse, Brazil)
  • Fortunato G et al. (2018) Recovery of pulmonary structure and exercise capacity by treatment with granulocyte-colony stimulating factor (G-CSF) in a mouse model of emphysema. Pulm Pharmacol Ther. 2014 Apr;27(2):144-9. (Treadmill Oxylet, mouse, Brazil)
  • Bojados M et al. (2014) The long-term consequences of the exposure to increasing gravity levels on the muscular, vestibular and cognitive functions in adult mice. Behav Brain Res. 2014 May 1;264:64-73. (VOmax, mouse, France)
  • Casuso Ra et al. (2013) Ergogenic effects of quercetin supplementation in trained rats. J. Int. Society of Sports Nutrition. 10:3-7 (LE8710R, VO2 mx, exhaustion, rat, Spain)
  • Vidal D at al. (2012) Alterations in pulmonary structure by elastase administration in a model of emphysema in mice is associated with functional disturbances. Rev Port Pneumol. 2012 May-Jun;18(3):128-36. (LE8700, Oxylet, mouse, Brazil)
  • Bojados M et al. (2011) Exposure to hypergravity during specific developmental periods differentially affects metabolism and vestibular reactions in adult C57BL /6j mice. Eur J Neurosci. 2011 Dec;34(12):2024-34. (VO2max, mouse, France)
  • Penna F et al. (2011) Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise. J Cachexia Sarcopenia Muscle. 2011 Jun;2(2):95-104. (VO2max, mouse, Spain)
  • Pratte M et al. (2011) Progressive motor and respiratory metabolism deficits in post-weaning Mecp2-null male mice. Behav Brain Res. 2011 Jan 1;216(1):313-20. (Treadmill Oxylet, mouse, France)
  • Macambira SG et al. (2009) FASEB J. Granulocyte colony-stimulating factor treatment in chronic Chagas disease: preservation and improvement of cardiac structure and function. 2009 Nov;23(11):3843-50. (VO2max, mouse, Brazil)


How to order





Rat Single lane Touchscreen Treadmill for calorimetry including shock source




Mice single lane Touchscreen Treadmill including shock source (needs air tight cover component LE8708CO).




Air tight cover component for LE8708TS






LE4002FL Air Flow regulator and switching unit




LE405 O2/CO2 Gas Analyser




LE1334 Reference Chamber






METABOLISM V3.0 Metabolism studies Platform. Needs Metabolism Experimental Modules for Calorimetry.




METAOXY Metabolism Software Experimental Module - Calorimetry (respiratory metabolism).


How to order

Please contact our local delegates or contact us directly for receiving a quote.


Key features

  • New control unit with integrated touchscreen graphic user interface
  • Adjustable belt speed up to 150 cm/s and belt slope from -25 to +25 degrees
  • Models mice and rats
  • Constant electrical shock intensity (adjustable from 0 to 2 mA)
  • Indirect calorimetry measurement for VOmax determination
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