Prepulse inhibition of startle reflex test (PPI)

Related Panlab Integrated Solutions


Prepulse Inhibition (PPI) paradigm is commonly used to evaluate sensorimotor gating as well as attentional processes involved in information selection processing.

The startle response is a brainstem reflex elicited by an unexpected acoustic or tactile stimulus. In the prepulse inhibition test, sensorimotor gating is assessed by evaluating the characteristics of the innate reduction of the startle reflex induced by a weak prestimulus.

This test measures pre-attentive processes that operate outside of conscious awareness and is widely used in animal models of diseases marked by an inability to inhibit, or "gate" irrelevant information in sensory, motor, or cognitive domains.

Related Panlab Integrated Solutions

Startle/ppi box (Panlab) - (n) subjects

The system is composed of a chamber & accessories, a holder and a software. The standard configuration uses acoustic stimuli for startle reflex induction.

Additional option for tactile stimuli (the source of air and regulators are not included).




Reasons for choosing this test

  • Reproduces the same paradigm used in humans to detect attentional and sensorimotor gating disorders
  • Objective measurement: automated detection of startle reflex
  • Sensitive for both rats and mice

Reasons for not choosing this test

  • Restraint conditions (habituation phase needed)
  • Influenced by non-specific effects on sensorimotor gating
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