Randall Selitto test

Description

The Randall-Selitto test consists in an application of a uniformly increasing pressure on the paw to assess the threshold response to pain.

The intensity of pressure causing an escape reaction is defined as the withdrawal threshold.

Reasons for choosing this test

Mechanical pain sensitivity (analgesia and hyperalgesia)
Left and right paw discrimination
Allows multiple measurements in the same animal

Reasons for not choosing this test

Mainly spinal response
Animal habituation is critical for obtaining reliable data
Subjective measurement: visual detection of animal reaction time
Widely used in rat (paw application), needs more expertise in mice (tail or paw application)

Related human disease/applications

Drug screening
Phenotyping
Neuropathy
Inflammation
Post-operative pain

Research areas

Pain and Analgesia

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More information

Panlab | Harvard Apparatus