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Panlab | Harvard Apparatus

 

Randall Selitto test

Description
Related Panlab Integrated Solutions

Description

The Randall-Selitto test consists in an application of a uniformly increasing pressure on the paw to assess the threshold response to pain.

The intensity of pressure causing an escape reaction is defined as the withdrawal threshold.

Related Panlab Integrated Solutions

PAW TAIL PRESSURE SYSTEM - SEDACOM (Panlab)

PINCHER TEST (Bioseb)

SMALGO SYSTEM (Bioseb)

 

Reasons for choosing this test

  • Mechanical pain sensitivity (analgesia and hyperalgesia)
  • Left and right paw discrimination
  • Allows multiple measurements in the same animal

Reasons for not choosing this test

  • Mainly spinal response
  • Animal habituation is critical for obtaining reliable data
  • Subjective measurement: visual detection of animal reaction time
  • Widely used in rat (paw application), needs more expertise in mice (tail or paw application)

Related human disease/applications

  • Drug screening
  • Phenotyping
  • Neuropathy
  • Inflammation
  • Post-operative pain

Research areas