Tail suspension test

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The tail-suspension test was developed as an alternative to the Forced Swimming test, yet the concept remains the same.

Rodents, suspended by their tail, innately attempt to escape from this aversive situation. However, following failed attempts to escape, they experience despair and become immobile. The magnitude of immobility is considered to be correlated with the depressive-like state of the subjects and is significantly decreased by antidepressants.

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  • FREEZEFRAME software



Reasons for choosing this test

  • Despair model
  • High predictability for antidepressant effects in humans
  • Based on innate behaviors
  • Widely used in literature
  • Simple to set up and use
  • Short-lasting experiment (no more than 5-10 min)
  • Can be automatized (measurement subjectivity)

Reasons for not choosing this test

  • Repeated exposition induces habituation
  • Can only be assessed in mice
  • Difficult with some mice strains (C57BL/6)
  • Repeated exposition induces habituation
  • Influenced by non-specific changes in motor performances
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