Para estudiar los efectos reforzantes de las drogas

Puntos clave
Como pedirlo


The Panlab spatial place preference box is an experimental chamber developed with the aim to optimise place preference and aversion studies in small laboratory animals, especially mice. The design of the box is fruit of a close collaboration with eminent Professor Dr. Rafael Maldonado and Dr. Olga Valverde from the Laboratory of Neuropharmacology in Barcelona (Spain). 

The apparatus consists in a box with two equally sized compartments interconnected by a rectangular corridor. Originally, the compartments are differentiated by the motifs painted on the walls (dots or stripes) and the colour (different shade of grey tones, light or dark) and texture (smooth or rough) of the floor. The innovation brought by the Panlab box is the possibility to combine a new additional spatial dimension to allow the animal differentiate the different compartments in a more discriminative manner. Transparent walls are also used to minimize the time the animal spent in the corridor. 

The introduction of these new discriminative elements allows:

  • optimising the results obtained in the place preference and aversion paradigms (low variability in the response, reduced number of animals per group...)
  • organizing the discriminative elements in a wide variety of configurations for studies evaluating spatial or contextual memory
  • using the elements as discriminative cues associated with drug exposure in diverse other experimental designs.

The Panlab spatial place preference box can be associated with the weight transducer technology (and PPC win software) or video-tracking system (SMART software) for detection and analysis of animal position throughout the test.



Box Dimensions for MICE

Total (ext.): 46 (w) x 27 (d) x 25 (h) cm; Compartments (int.): 20 (w) x 18 (d) x 25 (h) cm; Corridor (int.): 20 (w) x 7 (d) x 25 (h) cm

Box Dimensions or RAT

Total (ext.): 88 (w) x 47 (d) x 45 (h) cm; Compartments (int.); 40 (w) x 34 (d) x 45 (h) cm; Corridor (int.); 25 (w) x 13 (d) x 45 (h) cm

Reversible Floor texture

One side rough, one side smooth

Walls Width

6 mm

Material Composition


Position detection technique

Weight transducers or video tracking

Automated weight transducer - Connection of several units to PC

Neither PC interface nor PC card are required. One cable connects all units to the PC.

Automated weight transducer - Power Requirement

110/220 V, 50/60 Hz


CE Compliant


  • Klawonn AM et al. (2018) Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity. Front Mol Neurosci. 2018; 11: 139 (Spatial CPP, mice, Sweden, USA)
  • Bariselli S et al. (2018) SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction. Front Mol Neurosci. 2018 Oct 11;11:360 (spatial CPP, mice, Switzerland)
  • Bariselli S et al. (2018) Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction. Nat Commun. 2018 Aug 9;9(1):3173. (spatial CPP, mice, Switzerland)
  • Klawonn AM et al. (2018) Motivational valence is determined by striatal melanocortin 4 receptors. J Clin Invest. 2018 Jul 2;128(7):3160-3170 (Spatial CPP, mice, Sweden, USA)
  • Stojakovic A et al. (2018) Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice. Neuropsychopharmacology. 2018 Jun;43(7):1548-1556. (spatial CPP, mice, Sweden, Poland)
  • Fritz et al. (2018) Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion. Brain, Behavior, and Immunity. Volume 67, January 2018, Pages 54-58. (spatial CPP, mice, Sweden)
  • Zambrana-InfantesE et al. (2018) Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice. Pharmacology Biochemistry and Behavior. 2018 Jan 166:1-12 (spatial CPP, mice, Spain)
  • Klawonn AM et al. (2017) The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum. Front Pharmacol. 2017 Oct 10;8:714. (spatial CPP, mice, Sweden)
  • Fritz M et al. (2016). Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest. 2016 Feb;126(2):695-705. (Spatial CPP, mice, Sweden, USA)
  • Bernardi RE et al. (2015) Sex differences in dopamine binding and modafinil conditioned place preference in mice. Drug Alcohol Depend. 2015 Oct 1;155:37-44. (spatial CPP, mice, Germany)
  • Hyatt WS et al. (2014) Δ9-THC exposure attenuates aversive effects and reveals appetitive effects of K2/'Spice' constituent JWH-018 in mice. Behav Pharmacol. 2014 Jun;25(3):253-7. (spatial CPP, mouse, USA)
  • Bilbao A et al. (2013) Oleoylethanolamide dose‐dependently attenuates cocaine‐induced behaviours through a PPARα receptor‐independent mechanism. Addiction Biology, Volume 18, Issue 1, pages 78–87. (spatial CPP, mouse, Germany, Spain)
  • Garcia-Carmona JA et al. (2012) Restricted role of CRF1 receptor for the activity of brainstem catecholaminergic neurons in the negative state of morphine withdrawal. Psychopharmacology (Berl). 2012 Mar;220(2):379-93. (spatial CPP, conditioning place aversion, mouse, Spain).
  • Gómez-Milanés I et al. (2012) Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice. Neurochem Int. 2012 Aug;61(3):433-40. (spatial CPP, conditioning place aversion, mouse, Spain).
  • González-Cuello A et al. (2010) Enhanced tyrosine hydroxylase phosphorylation in the nucleus accumbens and nucleus tractus solitarius-A2 cell group after morphine-conditioned place preference. Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):525-34. (spatial CPP, rat, Spain)
  • Parkitna JR et al. (2010) Loss of the serum response factor in the dopamine system leads to hyperactivity. FASEB J. 2010 Jul;24(7):2427-35. (spatial CPP, Germany)



Como pedirlo




Spatial Conditioned Place Preference for Rats



Spatial Conditioned Place Preference for Mice





Spatial Place Preference Rats-Position Detection Weight Cells



Spatial Place Preference Mice-Position Detection Weight Cells



PPCWIN Software (to be used with LE896/LE898)


Cómo pedir una orferta

Contacta nuestro distribuidor el más cercano o contáctanos directamente para recibir una oferta.


Puntos clave

  • Allows a multiple combination between the visual, tactile and spatial cues defining each compartment
  • Optimize the differentiation between compartments
  • Minimize initial place preference during pre-test phase
  • Transparent walls to minimize time spent in the corridor
  • Optimize subject detection using a video-tracking system


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