Conditioned place preference test

Description
Related Panlab Integrated Solutions

Description

The purpose of the Conditioned Place Preference test is to characterize the rewarding potential of a drug or other experimental condition.

The procedure involves operant conditioning of a preference for a particular environment that has been consistently paired with a subjective internal state induced by the tested substance or condition. If a drug has marked rewarding properties, the animal will spend more time in the compartment with which it was paired when subsequently tested without the drug. The conditioned place preference procedure is classically used for a long time to test the addictive liability of putative drugs of abuse in research as well as in pharmaceutical industry. The procedure may also be modified to determine whether genetically modified animals are more or less sensitive to the reinforcing effects of a drug.

Related Panlab Integrated Solutions


PLACE PREFERENCE BOX - BLACK & WHITE - PPCWIN (Panlab)


PLACE PREFERENCE BOX - SPATIAL - PPCWIN (Panlab)


PLACE PREFERENCE BOX - SPATIAL - SMART VIDEO TRACKING (Panlab)


 

Reasons for choosing this test

  • Detects putative reinforcing properties of drugs
  • Involves associative learning
  • Used for both rats and mice

Reasons for not choosing this test

  • Positive results do not imply that the animal will develop drug addiction (e.g. will display self-administration behavior)
  • The drug is given to the animal by the experimenter
  • Long and laborious procedure
  • Need highly controlled experimental conditions (noise, light, odor, handling…)
  • Changes in behavioral output can be brought by many cognitive and non-cognitive factors, such as alteration of learning, locomotor activity, vision...
 
 
 
 
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