Conducta & Fenotipaje
VivaMARS is a new activity solution specially designed to address all the needs of high efficiency in CROs for neurotoxicology and neuropharmacology studies.
Features & Benefits
Partnership with Data Science International (DSI)
DSI and Panlab brands, divisions of Harvard Bioscience Inc., are leading manufacturer of quality instrumentation for animal behavioral and physiology research. Representing over 50 years of experience and referenced in more than 7,000 peer-reviewed publications, our solutions are proven choices for a wide range of in vivo applications spanning neuroscience, toxicology, pharmacology and more. Our collective team is eager to share our expertise and support your research as we have with many of the world’s scientists for decades.
In the context of this partnership, DSI and Panlab features the new VivaMARS solution, a high-capacity activity monitoring system for pre-clinical applications.
The new system combines the Company’s high precision Panlab activity monitoring technology with the industry leading Ponemah™ pre-clinical data management software to create an integrated good laboratory practice (GLP) compliant solution. The system is ideally suited to meet the high throughput, automated pre-clinical safety and pharmacology testing needs of CROs and pharma, in addition to acute activity studies carried out by leading research and academic institutes.
For more information visit VivaMARS website
Smart I/O is an enhanced version of the Panlab SMART 3.0 video-tracking for the combined evaluation of behavior with the neural recording and stimulation (electrical and optogenetics).
The importance of the use of video recording and video tracking tools is signifi cant in this context for ensuring a reliable assessment of behavior in neuroscience research.
Panlab features the new OxyletPro waste collection cage for mice. A more comprehensive approach to understanding the animal body mass phenotype by combining the assessment of respiratory metabolism with digestive efficiency through the analysis of collected urine and feces.
OxyletPro’s full modular design allows for simple expandability. Configurations are available for home cage metabolism phenotyping with our Physiocage system and for cardiovascular studies with exercise physiology with our airtight treadmills.
Start with the configuration that meets your requirements today and expand as needs change and grow!
OxyletPro can be used in the following applications: obesity, diabetes, metabolic disorders, nutrition studies, drug screening, phenotyping and more!
RECORD-IT! MEDIA is the Panlab product specifically designed to record digital videos in laboratories and scientific environments in general.
RECORD-IT! MEDIA can record the live images of up to 8 cameras simultaneously into independent digital video files. RECORD-IT! MEDIA also provides a Player for the review of the recorder videos. Both video recording and video playing can be synchronized with third-party system.
RECORD-IT! MEDIA processes the images (frames) coming from the connected images sources (cameras). The cameras supported by RECORD-IT! MEDIA are digital USB cameras, webcam, WIA cameras, analog cameras and IP network cameras. RECORD-IT! MEDIA also provides some simulated live image video sources for demo purposes.
RECORD-IT! MEDIA player is compatible with a wide range of video formats.
The tail suspension test allows a fast and reliable screening of the psychotropic properties (anti-depressants, sedatives) of drugs on rodents.
The tail-suspension test was developed as an alternative to the Forced Swimming test, yet the concept remains the same. Rodents, suspended by their tail, innately attempt to escape from this aversive situation. However,following failed attempts to escape, they experience despair and become immobile. The magnitude of immobility is considered to be correlated with the depressive-like state of the subjects and is significantly decreased by antidepressants.
The parameters currently evaluated are:
The Panlab Tail suspension box (TST) consists in a box with 3 compartments, so to carry out experiment simultaneously on 3 experimental subjects at the same time.
NEW Modular Background Panels! The box is provided with modular background panels with 3 choices of colour (black/grey and white/translucid panels)
The box is also made of non-reflecting and odour-resistance material for an optimized use with a video-tracking system. Our user-friendly SMART video-tracking sofware is our recommend solution to run, record, analyse and replay the experiments at will.
The beam balance test (or beam walking assay) is used to assess fine motor coordination and balance in rodents, especially in experimental models associated with an alteration of the motor skills (brain injury, genetic manipulations, and/or pharmacological treatments…).
The goal of this test is for the subject to stay upright and walk across an elevated narrow beam to a safe box/platform. This test usually takes several consecutive days of test: some days of training and 1 day of testing. Performance on the beam is quantified by measuring the time it takes for the subject to cross the beam and the number of paw slips that occur in the process.
This task is particularly useful for detecting subtle deficits in motor skills and balance that may not be detected by other motor tests, such as the Rotarod.
The Panlab beam balance test is composed of:
The beam can be horizontal or the tripods height can be adjusted to make a slope.
The goal box and beams are easy to remove/assemble using manual screws below the beam.
The 76-116/LE782CN “catch net” can be used to ensure that the animals do not injure themselves if they fall (optional item).
The inclined geotaxis board (slant board) is mainly used to assess motor coordination in rodents when challenged on a sloped surface.
The subjects are placed individually on the sloped platform facing in a downward direction (negative geotaxis). The latency to turn and orient themselves to be facing up the slope is recorded. This can be repeated at varying inclines to assess motor coordination and righting.
Delays in the ability to reorient could be indicative of delays in motor, balance, or vestibular function.
The inclined geotaxis board consists of sloped platforms of varying angles from horizontal to the desktop (0° to 90°).
The foot misplacement corridor test is used for assessing motor coordination and balance (gait control) in small laboratory animal (rats and mice).
The foot misplacement corridor test is made of a narrow corridor with clear Plexiglas side walls and opened extremities connecting the corridor to two plastic home cages, one for each side. The floor of the corridor consists of removable metal bars. The animal is placed at one extremity of the corridor and is required to walk on the bars as if walking on a horizontal ladder. The use of a ladder allows observing separately the front and hind foot placement in order to accurately count the total number of foot misplacements (misseps).
The bars can be removed to vary the distance/space between the bars and make the test more difficult for the animal. The changes in bar spacing also prevent animals from learning the location of the bars and so minimize the ability of the animals to compensate for impairments through learning. The width of the corridor can be adjusted to the size of the animal to prevent the animal from turning around.
The system can be combined with the use of a video tracking system for video recording and eventually assess a global evaluation of the animal trajectory, displacement and speed during the test.
This test is a qualitative test with a high sensitivity to determine even subtle loss of movement capacity.
TThe tube dominance test is used for investigating social dominance in mice.
The apparatus consist of a narrow clear Perspex tube with two removable central doors. The tube is provided with two supporting paws for ensuring its stability during the test.
After being habituated to run through the tube individually, two mice are placed in the tube into opposite ends. Once both mice get close to the doors, the doors are opened and the dominant mice will makes the submissive mouse reverse until it get out of the tube. When one animal has all four paws out of the tube, it is declared the loser while the animal remaining inside the tube is the winner, ending the match.
The number of wins is reported as a percentage of total number of matches. Additional information about the social hierarchies can be gained with the measurement of additional parameters such as duration of each match, latency to exit the tube, and more.
The body reversal corridor is used for assessing muscle control and movement coordination in rats.
The apparatus consist of a narrow black Perspex corridor with a closed end. The corridor is provided with two supporting paws for ensuring its stability during the test.
The rat is placed in the corridor facing the closed end. The researcher evaluates the time spent by the animal to turn over (body reversal) and reach the opposite opened end of the corridor.